Cargando…
No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review
OBJECTIVES: The levels of some migraine biomarkers differ between episodic migraine (EM) and chronic migraine (CM), but information on C-reactive protein (CRP) levels in EM and CM is conflicting. Thus, this study aimed to evaluate CRP levels in participants with EM and CM in comparison to those in h...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597506/ https://www.ncbi.nlm.nih.gov/pubmed/36313504 http://dx.doi.org/10.3389/fneur.2022.1021065 |
_version_ | 1784816107210670080 |
---|---|
author | Park, Chae Gyu Lee, Sue Hyun Chu, Min Kyung |
author_facet | Park, Chae Gyu Lee, Sue Hyun Chu, Min Kyung |
author_sort | Park, Chae Gyu |
collection | PubMed |
description | OBJECTIVES: The levels of some migraine biomarkers differ between episodic migraine (EM) and chronic migraine (CM), but information on C-reactive protein (CRP) levels in EM and CM is conflicting. Thus, this study aimed to evaluate CRP levels in participants with EM and CM in comparison to those in healthy controls. METHODS: Plasma CRP levels were evaluated by high-sensitivity CRP tests in female participants with EM (n = 174) and CM (n = 191) and healthy controls (n = 50). RESULTS: The results showed no significant difference in CRP levels among the EM, CM, and control groups (median and interquartile range, 0.40 [0.15–0.70] mg/L vs. 0.40 [0.15–1.00] mg/L vs. 0.15 [0.15–0.90] mg/L, p = 0.991). The ratio of individuals with elevated CRP levels (>3.0 mg/L) did not significantly differ among the EM, CM, and control groups (3.4% [6/174] vs. 2.1% [4/191] vs. 0.0% [0/50], p = 0.876). Multivariable regression analyses revealed that CRP levels were not significantly associated with headache frequency per month (β = −0.076, p = 0.238), the severity of anxiety (Generalized Anxiety Disorder-7 score, β = 0.143, p = 0.886), and depression (Patient Health Questionnaire-9 score, β = 0.143, p = 0.886). Further, CRP levels did not significantly differ according to clinical characteristics, fibromyalgia, medication overuse, preventive treatment, and classes of preventive treatment medications. Among participants with a body mass index ≥25 kg/m(2), the CRP levels in EM (n = 41) and CM (n = 17) were numerically higher than those in the control (n = 6) (1.30 [0.28–4.25] mg/L vs. 1.10 [0.50–3.15] mg/L vs. 0.40 [0.15–0.83] mg/L, p = 0.249) but did not reach statistical significance. CONCLUSIONS: The interictal CRP level is not likely to be a biomarker for EM or CM. |
format | Online Article Text |
id | pubmed-9597506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95975062022-10-27 No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review Park, Chae Gyu Lee, Sue Hyun Chu, Min Kyung Front Neurol Neurology OBJECTIVES: The levels of some migraine biomarkers differ between episodic migraine (EM) and chronic migraine (CM), but information on C-reactive protein (CRP) levels in EM and CM is conflicting. Thus, this study aimed to evaluate CRP levels in participants with EM and CM in comparison to those in healthy controls. METHODS: Plasma CRP levels were evaluated by high-sensitivity CRP tests in female participants with EM (n = 174) and CM (n = 191) and healthy controls (n = 50). RESULTS: The results showed no significant difference in CRP levels among the EM, CM, and control groups (median and interquartile range, 0.40 [0.15–0.70] mg/L vs. 0.40 [0.15–1.00] mg/L vs. 0.15 [0.15–0.90] mg/L, p = 0.991). The ratio of individuals with elevated CRP levels (>3.0 mg/L) did not significantly differ among the EM, CM, and control groups (3.4% [6/174] vs. 2.1% [4/191] vs. 0.0% [0/50], p = 0.876). Multivariable regression analyses revealed that CRP levels were not significantly associated with headache frequency per month (β = −0.076, p = 0.238), the severity of anxiety (Generalized Anxiety Disorder-7 score, β = 0.143, p = 0.886), and depression (Patient Health Questionnaire-9 score, β = 0.143, p = 0.886). Further, CRP levels did not significantly differ according to clinical characteristics, fibromyalgia, medication overuse, preventive treatment, and classes of preventive treatment medications. Among participants with a body mass index ≥25 kg/m(2), the CRP levels in EM (n = 41) and CM (n = 17) were numerically higher than those in the control (n = 6) (1.30 [0.28–4.25] mg/L vs. 1.10 [0.50–3.15] mg/L vs. 0.40 [0.15–0.83] mg/L, p = 0.249) but did not reach statistical significance. CONCLUSIONS: The interictal CRP level is not likely to be a biomarker for EM or CM. Frontiers Media S.A. 2022-10-12 /pmc/articles/PMC9597506/ /pubmed/36313504 http://dx.doi.org/10.3389/fneur.2022.1021065 Text en Copyright © 2022 Park, Lee and Chu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Park, Chae Gyu Lee, Sue Hyun Chu, Min Kyung No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review |
title | No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review |
title_full | No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review |
title_fullStr | No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review |
title_full_unstemmed | No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review |
title_short | No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review |
title_sort | no change in interictal c-reactive protein levels in individuals with episodic and chronic migraine: a case-control study and literature review |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597506/ https://www.ncbi.nlm.nih.gov/pubmed/36313504 http://dx.doi.org/10.3389/fneur.2022.1021065 |
work_keys_str_mv | AT parkchaegyu nochangeininterictalcreactiveproteinlevelsinindividualswithepisodicandchronicmigraineacasecontrolstudyandliteraturereview AT leesuehyun nochangeininterictalcreactiveproteinlevelsinindividualswithepisodicandchronicmigraineacasecontrolstudyandliteraturereview AT chuminkyung nochangeininterictalcreactiveproteinlevelsinindividualswithepisodicandchronicmigraineacasecontrolstudyandliteraturereview |