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Why doesn't Ebola virus cause pandemics like SARS-CoV-2?

Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host...

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Autor principal: Popovic, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597532/
https://www.ncbi.nlm.nih.gov/pubmed/36312211
http://dx.doi.org/10.1016/j.mran.2022.100236
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author Popovic, Marko
author_facet Popovic, Marko
author_sort Popovic, Marko
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description Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CH(1.569)O(0.3281)N(0.2786)P(0.00173)S(0.00258). Standard Gibbs energy of biosynthesis of the Ebola virus nucleocapsid is -151.59 kJ/C-mol.
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spelling pubmed-95975322022-10-26 Why doesn't Ebola virus cause pandemics like SARS-CoV-2? Popovic, Marko Microb Risk Anal Article Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CH(1.569)O(0.3281)N(0.2786)P(0.00173)S(0.00258). Standard Gibbs energy of biosynthesis of the Ebola virus nucleocapsid is -151.59 kJ/C-mol. Elsevier B.V. 2022-12 2022-10-25 /pmc/articles/PMC9597532/ /pubmed/36312211 http://dx.doi.org/10.1016/j.mran.2022.100236 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Popovic, Marko
Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
title Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
title_full Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
title_fullStr Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
title_full_unstemmed Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
title_short Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
title_sort why doesn't ebola virus cause pandemics like sars-cov-2?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597532/
https://www.ncbi.nlm.nih.gov/pubmed/36312211
http://dx.doi.org/10.1016/j.mran.2022.100236
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