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D3AI-Spike: A deep learning platform for predicting binding affinity between SARS-CoV-2 spike receptor binding domain with multiple amino acid mutations and human angiotensin-converting enzyme 2

The number of SARS-CoV-2 spike Receptor Binding Domain (RBD) with multiple amino acid mutations is huge due to random mutations and combinatorial explosions, making it almost impossible to experimentally determine their binding affinities to human angiotensin-converting enzyme 2 (hACE2). Although co...

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Detalles Bibliográficos
Autores principales:	Han, Jiaxin, Liu, Tingting, Zhang, Xinben, Yang, Yanqing, Shi, Yulong, Li, Jintian, Ma, Minfei, Zhu, Weiliang, Gong, Likun, Xu, Zhijian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597563/ https://www.ncbi.nlm.nih.gov/pubmed/36327885 http://dx.doi.org/10.1016/j.compbiomed.2022.106212

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