Genomic Tools for the Characterization of Local Animal Genetic Resources: Application in Mascaruna Goat

SIMPLE SUMMARY: The Analysis of genomic data is an important resource for the effective management of small and endangered populations. The aim of this work was to study the genomic structure of a local goat named Mascaruna. Overall, the results indicate moderate genetic variability and a defined population structure and represent a starting point for the creation of monitoring and conservation plans. ABSTRACT: Italy contains a large number of local goat populations, some of which do not have a recognized genetic structure. The “Mascaruna” is a goat population reared for milk production in Sicily. In this study, a total of 72 individuals were genotyped with the Illumina Goat_IGGC_65K_v2 BeadChip with the aim to characterize the genetic diversity, population structure and relatedness with another 31 Italian goat populations. The results displayed a moderate level of genetic variability for Mascaruna, in concordance with the estimated values for Italian goats. Runs of homozygosity islands are linked to genes involved in milk production, immune response and local adaptation. Population structure analyses separated Mascaruna from the other goat populations, indicating a clear genetic differentiation. Although they are not conclusive, our current results represent a starting point for the creation of monitoring and conservation plans. Additional analyses and a wider sampling would contribute to refine and validate these results. Finally, our study describing the diversity and structure of Mascaruna confirms the usefulness of applied genomic analyses as valid tools for the study of the local uncharacterized genetic resources.