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Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders

Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ interneurons provide a quick and stable inhibitory input to pyramidal neurons and contribute to the generation of gamma oscill...

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Autores principales: Juarez, Pablo, Martínez Cerdeño, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597886/
https://www.ncbi.nlm.nih.gov/pubmed/36311505
http://dx.doi.org/10.3389/fpsyt.2022.913550
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author Juarez, Pablo
Martínez Cerdeño, Verónica
author_facet Juarez, Pablo
Martínez Cerdeño, Verónica
author_sort Juarez, Pablo
collection PubMed
description Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ interneurons provide a quick and stable inhibitory input to pyramidal neurons and contribute to the generation of gamma oscillations in the cortex. Their fast-firing rates, while advantageous for regulating cortical signaling, also leave them vulnerable to metabolic stress. Chandelier (Ch) cells are a type of PV+ interneuron that modulate the output of pyramidal neurons and synchronize spikes within neuron populations by directly innervating the pyramidal axon initial segment. Changes in the morphology and/or function of PV+ interneurons, mostly of Ch cells, are linked to neurological disorders. In ASD, the number of PV+ Ch cells is decreased across several cortical areas. Changes in the morphology and/or function of PV+ interneurons have also been linked to schizophrenia, epilepsy, and bipolar disorder. Herein, we review the role of PV and PV+ Ch cell alterations in ASD and other psychiatric disorders.
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spelling pubmed-95978862022-10-27 Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders Juarez, Pablo Martínez Cerdeño, Verónica Front Psychiatry Psychiatry Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ interneurons provide a quick and stable inhibitory input to pyramidal neurons and contribute to the generation of gamma oscillations in the cortex. Their fast-firing rates, while advantageous for regulating cortical signaling, also leave them vulnerable to metabolic stress. Chandelier (Ch) cells are a type of PV+ interneuron that modulate the output of pyramidal neurons and synchronize spikes within neuron populations by directly innervating the pyramidal axon initial segment. Changes in the morphology and/or function of PV+ interneurons, mostly of Ch cells, are linked to neurological disorders. In ASD, the number of PV+ Ch cells is decreased across several cortical areas. Changes in the morphology and/or function of PV+ interneurons have also been linked to schizophrenia, epilepsy, and bipolar disorder. Herein, we review the role of PV and PV+ Ch cell alterations in ASD and other psychiatric disorders. Frontiers Media S.A. 2022-10-12 /pmc/articles/PMC9597886/ /pubmed/36311505 http://dx.doi.org/10.3389/fpsyt.2022.913550 Text en Copyright © 2022 Juarez and Martínez Cerdeño. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Juarez, Pablo
Martínez Cerdeño, Verónica
Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
title Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
title_full Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
title_fullStr Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
title_full_unstemmed Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
title_short Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
title_sort parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597886/
https://www.ncbi.nlm.nih.gov/pubmed/36311505
http://dx.doi.org/10.3389/fpsyt.2022.913550
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