Exploiting the distinctive properties of the bacterial and human MutS homolog sliding clamps on mismatched DNA

MutS homologs (MSHs) are highly conserved core components of DNA mismatch repair. Mismatch recognition provokes ATP-binding by MSH proteins that drives a conformational transition from a short-lived lesion-searching clamp to an extremely stable sliding clamp on the DNA. Here, we have expanded on pre...

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Detalles Bibliográficos
Autores principales: Britton, Brooke M., London, James A., Martin-Lopez, Juana, Jones, Nathan D., Liu, Jiaquan, Lee, Jong-Bong, Fishel, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597889/
https://www.ncbi.nlm.nih.gov/pubmed/36126773
http://dx.doi.org/10.1016/j.jbc.2022.102505

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