A programmable system to methylate and demethylate N(6)-methyladenosine (m(6)A) on specific RNA transcripts in mammalian cells

RNA N(6)-methyladenosine (m(6)A) is the most abundant internal mRNA modification and forms part of an epitranscriptomic system that modulates RNA function. m(6)A is reversibly catalyzed by specific enzymes, and those modifications can be recognized by RNA-binding proteins that in turn regulate biolo...

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Detalles Bibliográficos
Autores principales: Chang, Chen, Ma, Gang, Cheung, Edwin, Hutchins, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597892/
https://www.ncbi.nlm.nih.gov/pubmed/36162509
http://dx.doi.org/10.1016/j.jbc.2022.102525

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