Cargando…

Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration

Additive manufacturing has been used to develop a variety of scaffold designs for clinical and industrial applications. Mechanical properties (i.e., compression, tension, bending, and torsion response) of these scaffolds are significantly important for load-bearing orthopaedic implants. In this stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Naghavi, Seyed Ataollah, Tamaddon, Maryam, Marghoub, Arsalan, Wang, Katherine, Babamiri, Behzad Bahrami, Hazeli, Kavan, Xu, Wei, Lu, Xin, Sun, Changning, Wang, Liqing, Moazen, Mehran, Wang, Ling, Li, Dichen, Liu, Chaozong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598079/
https://www.ncbi.nlm.nih.gov/pubmed/36290472
http://dx.doi.org/10.3390/bioengineering9100504
_version_ 1784816242805178368
author Naghavi, Seyed Ataollah
Tamaddon, Maryam
Marghoub, Arsalan
Wang, Katherine
Babamiri, Behzad Bahrami
Hazeli, Kavan
Xu, Wei
Lu, Xin
Sun, Changning
Wang, Liqing
Moazen, Mehran
Wang, Ling
Li, Dichen
Liu, Chaozong
author_facet Naghavi, Seyed Ataollah
Tamaddon, Maryam
Marghoub, Arsalan
Wang, Katherine
Babamiri, Behzad Bahrami
Hazeli, Kavan
Xu, Wei
Lu, Xin
Sun, Changning
Wang, Liqing
Moazen, Mehran
Wang, Ling
Li, Dichen
Liu, Chaozong
author_sort Naghavi, Seyed Ataollah
collection PubMed
description Additive manufacturing has been used to develop a variety of scaffold designs for clinical and industrial applications. Mechanical properties (i.e., compression, tension, bending, and torsion response) of these scaffolds are significantly important for load-bearing orthopaedic implants. In this study, we designed and additively manufactured porous metallic biomaterials based on two different types of triply periodic minimal surface structures (i.e., gyroid and diamond) that mimic the mechanical properties of bone, such as porosity, stiffness, and strength. Physical and mechanical properties, including compressive, tensile, bending, and torsional stiffness and strength of the developed scaffolds, were then characterised experimentally and numerically using finite element method. Sheet thickness was constant at 300 μm, and the unit cell size was varied to generate different pore sizes and porosities. Gyroid scaffolds had a pore size in the range of 600–1200 μm and a porosity in the range of 54–72%, respectively. Corresponding values for the diamond were 900–1500 μm and 56–70%. Both structure types were validated experimentally, and a wide range of mechanical properties (including stiffness and yield strength) were predicted using the finite element method. The stiffness and strength of both structures are comparable to that of cortical bone, hence reducing the risks of scaffold failure. The results demonstrate that the developed scaffolds mimic the physical and mechanical properties of cortical bone and can be suitable for bone replacement and orthopaedic implants. However, an optimal design should be chosen based on specific performance requirements.
format Online
Article
Text
id pubmed-9598079
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95980792022-10-27 Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration Naghavi, Seyed Ataollah Tamaddon, Maryam Marghoub, Arsalan Wang, Katherine Babamiri, Behzad Bahrami Hazeli, Kavan Xu, Wei Lu, Xin Sun, Changning Wang, Liqing Moazen, Mehran Wang, Ling Li, Dichen Liu, Chaozong Bioengineering (Basel) Article Additive manufacturing has been used to develop a variety of scaffold designs for clinical and industrial applications. Mechanical properties (i.e., compression, tension, bending, and torsion response) of these scaffolds are significantly important for load-bearing orthopaedic implants. In this study, we designed and additively manufactured porous metallic biomaterials based on two different types of triply periodic minimal surface structures (i.e., gyroid and diamond) that mimic the mechanical properties of bone, such as porosity, stiffness, and strength. Physical and mechanical properties, including compressive, tensile, bending, and torsional stiffness and strength of the developed scaffolds, were then characterised experimentally and numerically using finite element method. Sheet thickness was constant at 300 μm, and the unit cell size was varied to generate different pore sizes and porosities. Gyroid scaffolds had a pore size in the range of 600–1200 μm and a porosity in the range of 54–72%, respectively. Corresponding values for the diamond were 900–1500 μm and 56–70%. Both structure types were validated experimentally, and a wide range of mechanical properties (including stiffness and yield strength) were predicted using the finite element method. The stiffness and strength of both structures are comparable to that of cortical bone, hence reducing the risks of scaffold failure. The results demonstrate that the developed scaffolds mimic the physical and mechanical properties of cortical bone and can be suitable for bone replacement and orthopaedic implants. However, an optimal design should be chosen based on specific performance requirements. MDPI 2022-09-24 /pmc/articles/PMC9598079/ /pubmed/36290472 http://dx.doi.org/10.3390/bioengineering9100504 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naghavi, Seyed Ataollah
Tamaddon, Maryam
Marghoub, Arsalan
Wang, Katherine
Babamiri, Behzad Bahrami
Hazeli, Kavan
Xu, Wei
Lu, Xin
Sun, Changning
Wang, Liqing
Moazen, Mehran
Wang, Ling
Li, Dichen
Liu, Chaozong
Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration
title Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration
title_full Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration
title_fullStr Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration
title_full_unstemmed Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration
title_short Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration
title_sort mechanical characterisation and numerical modelling of tpms-based gyroid and diamond ti6al4v scaffolds for bone implants: an integrated approach for translational consideration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598079/
https://www.ncbi.nlm.nih.gov/pubmed/36290472
http://dx.doi.org/10.3390/bioengineering9100504
work_keys_str_mv AT naghaviseyedataollah mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT tamaddonmaryam mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT marghoubarsalan mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT wangkatherine mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT babamiribehzadbahrami mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT hazelikavan mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT xuwei mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT luxin mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT sunchangning mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT wangliqing mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT moazenmehran mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT wangling mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT lidichen mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration
AT liuchaozong mechanicalcharacterisationandnumericalmodellingoftpmsbasedgyroidanddiamondti6al4vscaffoldsforboneimplantsanintegratedapproachfortranslationalconsideration