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VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study

Previous studies have reported a close correlation between vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, and human T-cell leukemia virus 1 (HTLV-1). However, an association between genetic characteristics related to VEGF and HTLV-1 infection has not yet be...

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Autores principales: Shimizu, Yuji, Yamanashi, Hirotomo, Miyata, Jun, Takada, Midori, Noguchi, Yuko, Honda, Yukiko, Nonaka, Fumiaki, Nakamichi, Seiko, Nagata, Yasuhiro, Maeda, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598135/
https://www.ncbi.nlm.nih.gov/pubmed/36290496
http://dx.doi.org/10.3390/bioengineering9100527
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author Shimizu, Yuji
Yamanashi, Hirotomo
Miyata, Jun
Takada, Midori
Noguchi, Yuko
Honda, Yukiko
Nonaka, Fumiaki
Nakamichi, Seiko
Nagata, Yasuhiro
Maeda, Takahiro
author_facet Shimizu, Yuji
Yamanashi, Hirotomo
Miyata, Jun
Takada, Midori
Noguchi, Yuko
Honda, Yukiko
Nonaka, Fumiaki
Nakamichi, Seiko
Nagata, Yasuhiro
Maeda, Takahiro
author_sort Shimizu, Yuji
collection PubMed
description Previous studies have reported a close correlation between vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, and human T-cell leukemia virus 1 (HTLV-1). However, an association between genetic characteristics related to VEGF and HTLV-1 infection has not yet been reported. Because the VEGF polymorphism rs3025039 is inversely associated with serum concentrations of VEGF, we focus on rs3025039 in the present study. To clarify the association between the VEGF polymorphism rs3025039 and HTLV-1 infection, a cross-sectional study of 1924 Japanese individuals aged 60–79 years who participated in general health check-ups was conducted. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) for HTLV-1 infection in relation to rs3025039 genotype were calculated with adjustment for known confounders. Compared with rs3025039 CC-homozygotes, (T) allele carriers had a significantly lower OR for HTLV-1 infection. The adjusted OR and 95% CI for HTLV-1 infection was 0.70 (0.54–0.91) (p = 0.009). Genetic characteristics related to lower angiogenesis activity might be associated with a lower chance of establishing HTLV-1 infection. Although further investigation is necessary, angiogenesis might play a crucial role in the establishment of HTLV-1 infection.
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spelling pubmed-95981352022-10-27 VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study Shimizu, Yuji Yamanashi, Hirotomo Miyata, Jun Takada, Midori Noguchi, Yuko Honda, Yukiko Nonaka, Fumiaki Nakamichi, Seiko Nagata, Yasuhiro Maeda, Takahiro Bioengineering (Basel) Article Previous studies have reported a close correlation between vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, and human T-cell leukemia virus 1 (HTLV-1). However, an association between genetic characteristics related to VEGF and HTLV-1 infection has not yet been reported. Because the VEGF polymorphism rs3025039 is inversely associated with serum concentrations of VEGF, we focus on rs3025039 in the present study. To clarify the association between the VEGF polymorphism rs3025039 and HTLV-1 infection, a cross-sectional study of 1924 Japanese individuals aged 60–79 years who participated in general health check-ups was conducted. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) for HTLV-1 infection in relation to rs3025039 genotype were calculated with adjustment for known confounders. Compared with rs3025039 CC-homozygotes, (T) allele carriers had a significantly lower OR for HTLV-1 infection. The adjusted OR and 95% CI for HTLV-1 infection was 0.70 (0.54–0.91) (p = 0.009). Genetic characteristics related to lower angiogenesis activity might be associated with a lower chance of establishing HTLV-1 infection. Although further investigation is necessary, angiogenesis might play a crucial role in the establishment of HTLV-1 infection. MDPI 2022-10-06 /pmc/articles/PMC9598135/ /pubmed/36290496 http://dx.doi.org/10.3390/bioengineering9100527 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimizu, Yuji
Yamanashi, Hirotomo
Miyata, Jun
Takada, Midori
Noguchi, Yuko
Honda, Yukiko
Nonaka, Fumiaki
Nakamichi, Seiko
Nagata, Yasuhiro
Maeda, Takahiro
VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study
title VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study
title_full VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study
title_fullStr VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study
title_full_unstemmed VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study
title_short VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study
title_sort vegf polymorphism rs3025039 and human t-cell leukemia virus 1 (htlv-1) infection among older japanese individuals: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598135/
https://www.ncbi.nlm.nih.gov/pubmed/36290496
http://dx.doi.org/10.3390/bioengineering9100527
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