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Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598168/ https://www.ncbi.nlm.nih.gov/pubmed/36290801 http://dx.doi.org/10.3390/antiox11102078 |
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author | Clergue-Duval, Virgile Coulbault, Laurent Questel, Frank Cabé, Nicolas Laniepce, Alice Delage, Clément Boudehent, Céline Bloch, Vanessa Segobin, Shailendra Naassila, Mickael Pitel, Anne-Lise Vorspan, Florence |
author_facet | Clergue-Duval, Virgile Coulbault, Laurent Questel, Frank Cabé, Nicolas Laniepce, Alice Delage, Clément Boudehent, Céline Bloch, Vanessa Segobin, Shailendra Naassila, Mickael Pitel, Anne-Lise Vorspan, Florence |
author_sort | Clergue-Duval, Virgile |
collection | PubMed |
description | Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol use disorders (AUD) associated with pharmacological dependence suffer from repetitive events of alcohol withdrawal (AW). If those AW are not managed by adequate medical and pharmacological treatment, they may evolve into severe AW, or be complicated by epileptic seizure or delirium tremens (DT). In addition, we suggest that AW favors the occurrence of Wernicke’s encephalopathy (WE) in patients with known or unknown thiamine depletion. We reviewed the literature on oxidative stress as a core mechanism in brain suffering linked with those conditions: AW, epileptic seizure, DT and WE. Thus, we propose perspectives to further develop research projects aiming at better identifying oxidative stress brain damage related to AW, assessing the effect of repetitive episodes of AW, and their long-term cognitive consequences. This research field should develop neuroprotective strategies during AW itself or during the periwithdrawal period. This could contribute to the prevention of severe alcohol-related brain damage and cognitive impairments. |
format | Online Article Text |
id | pubmed-9598168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95981682022-10-27 Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? Clergue-Duval, Virgile Coulbault, Laurent Questel, Frank Cabé, Nicolas Laniepce, Alice Delage, Clément Boudehent, Céline Bloch, Vanessa Segobin, Shailendra Naassila, Mickael Pitel, Anne-Lise Vorspan, Florence Antioxidants (Basel) Review Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol use disorders (AUD) associated with pharmacological dependence suffer from repetitive events of alcohol withdrawal (AW). If those AW are not managed by adequate medical and pharmacological treatment, they may evolve into severe AW, or be complicated by epileptic seizure or delirium tremens (DT). In addition, we suggest that AW favors the occurrence of Wernicke’s encephalopathy (WE) in patients with known or unknown thiamine depletion. We reviewed the literature on oxidative stress as a core mechanism in brain suffering linked with those conditions: AW, epileptic seizure, DT and WE. Thus, we propose perspectives to further develop research projects aiming at better identifying oxidative stress brain damage related to AW, assessing the effect of repetitive episodes of AW, and their long-term cognitive consequences. This research field should develop neuroprotective strategies during AW itself or during the periwithdrawal period. This could contribute to the prevention of severe alcohol-related brain damage and cognitive impairments. MDPI 2022-10-21 /pmc/articles/PMC9598168/ /pubmed/36290801 http://dx.doi.org/10.3390/antiox11102078 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Clergue-Duval, Virgile Coulbault, Laurent Questel, Frank Cabé, Nicolas Laniepce, Alice Delage, Clément Boudehent, Céline Bloch, Vanessa Segobin, Shailendra Naassila, Mickael Pitel, Anne-Lise Vorspan, Florence Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? |
title | Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? |
title_full | Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? |
title_fullStr | Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? |
title_full_unstemmed | Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? |
title_short | Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? |
title_sort | alcohol withdrawal is an oxidative stress challenge for the brain: does it pave the way toward severe alcohol-related cognitive impairment? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598168/ https://www.ncbi.nlm.nih.gov/pubmed/36290801 http://dx.doi.org/10.3390/antiox11102078 |
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