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Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?

Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol...

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Autores principales: Clergue-Duval, Virgile, Coulbault, Laurent, Questel, Frank, Cabé, Nicolas, Laniepce, Alice, Delage, Clément, Boudehent, Céline, Bloch, Vanessa, Segobin, Shailendra, Naassila, Mickael, Pitel, Anne-Lise, Vorspan, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598168/
https://www.ncbi.nlm.nih.gov/pubmed/36290801
http://dx.doi.org/10.3390/antiox11102078
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author Clergue-Duval, Virgile
Coulbault, Laurent
Questel, Frank
Cabé, Nicolas
Laniepce, Alice
Delage, Clément
Boudehent, Céline
Bloch, Vanessa
Segobin, Shailendra
Naassila, Mickael
Pitel, Anne-Lise
Vorspan, Florence
author_facet Clergue-Duval, Virgile
Coulbault, Laurent
Questel, Frank
Cabé, Nicolas
Laniepce, Alice
Delage, Clément
Boudehent, Céline
Bloch, Vanessa
Segobin, Shailendra
Naassila, Mickael
Pitel, Anne-Lise
Vorspan, Florence
author_sort Clergue-Duval, Virgile
collection PubMed
description Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol use disorders (AUD) associated with pharmacological dependence suffer from repetitive events of alcohol withdrawal (AW). If those AW are not managed by adequate medical and pharmacological treatment, they may evolve into severe AW, or be complicated by epileptic seizure or delirium tremens (DT). In addition, we suggest that AW favors the occurrence of Wernicke’s encephalopathy (WE) in patients with known or unknown thiamine depletion. We reviewed the literature on oxidative stress as a core mechanism in brain suffering linked with those conditions: AW, epileptic seizure, DT and WE. Thus, we propose perspectives to further develop research projects aiming at better identifying oxidative stress brain damage related to AW, assessing the effect of repetitive episodes of AW, and their long-term cognitive consequences. This research field should develop neuroprotective strategies during AW itself or during the periwithdrawal period. This could contribute to the prevention of severe alcohol-related brain damage and cognitive impairments.
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spelling pubmed-95981682022-10-27 Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? Clergue-Duval, Virgile Coulbault, Laurent Questel, Frank Cabé, Nicolas Laniepce, Alice Delage, Clément Boudehent, Céline Bloch, Vanessa Segobin, Shailendra Naassila, Mickael Pitel, Anne-Lise Vorspan, Florence Antioxidants (Basel) Review Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol use disorders (AUD) associated with pharmacological dependence suffer from repetitive events of alcohol withdrawal (AW). If those AW are not managed by adequate medical and pharmacological treatment, they may evolve into severe AW, or be complicated by epileptic seizure or delirium tremens (DT). In addition, we suggest that AW favors the occurrence of Wernicke’s encephalopathy (WE) in patients with known or unknown thiamine depletion. We reviewed the literature on oxidative stress as a core mechanism in brain suffering linked with those conditions: AW, epileptic seizure, DT and WE. Thus, we propose perspectives to further develop research projects aiming at better identifying oxidative stress brain damage related to AW, assessing the effect of repetitive episodes of AW, and their long-term cognitive consequences. This research field should develop neuroprotective strategies during AW itself or during the periwithdrawal period. This could contribute to the prevention of severe alcohol-related brain damage and cognitive impairments. MDPI 2022-10-21 /pmc/articles/PMC9598168/ /pubmed/36290801 http://dx.doi.org/10.3390/antiox11102078 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Clergue-Duval, Virgile
Coulbault, Laurent
Questel, Frank
Cabé, Nicolas
Laniepce, Alice
Delage, Clément
Boudehent, Céline
Bloch, Vanessa
Segobin, Shailendra
Naassila, Mickael
Pitel, Anne-Lise
Vorspan, Florence
Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
title Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
title_full Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
title_fullStr Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
title_full_unstemmed Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
title_short Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?
title_sort alcohol withdrawal is an oxidative stress challenge for the brain: does it pave the way toward severe alcohol-related cognitive impairment?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598168/
https://www.ncbi.nlm.nih.gov/pubmed/36290801
http://dx.doi.org/10.3390/antiox11102078
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