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Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair

Thoracic endovascular aortic repair (TEVAR) of aortic aneurysms and dissections involving the arch has evolved over the last two decades. Compared to conventional surgical methods, endovascular repair offers a less invasive treatment option with lower risk and faster recovery. Endografts used in TEV...

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Autores principales: Sengupta, Sampad, Zhu, Yu, Hamady, Mohamad, Xu, Xiao Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598215/
https://www.ncbi.nlm.nih.gov/pubmed/36290541
http://dx.doi.org/10.3390/bioengineering9100573
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author Sengupta, Sampad
Zhu, Yu
Hamady, Mohamad
Xu, Xiao Yun
author_facet Sengupta, Sampad
Zhu, Yu
Hamady, Mohamad
Xu, Xiao Yun
author_sort Sengupta, Sampad
collection PubMed
description Thoracic endovascular aortic repair (TEVAR) of aortic aneurysms and dissections involving the arch has evolved over the last two decades. Compared to conventional surgical methods, endovascular repair offers a less invasive treatment option with lower risk and faster recovery. Endografts used in TEVAR vary in design depending on the procedure and application. Novel endografts (e.g., branched stent-graft) were developed to ensure perfusion of blood to the supra-aortic vessels, but their haemodynamic performance and long-term durability have not been adequately studied. This review focuses on the use of computational modelling to study haemodynamics in commercially available endografts designed for complex aortic arch repair. First, we summarise the currently adopted workflow for computational fluid dynamics (CFD) modelling, including geometry reconstruction, boundary conditions, flow models, and haemodynamic metrics of interest. This is followed by a review of recently (2010-present) published CFD studies on complex aortic arch repair, using both idealized and patient-specific models. Finally, we introduce some of the promising techniques that can be potentially applied to predict post-operative outcomes.
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spelling pubmed-95982152022-10-27 Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair Sengupta, Sampad Zhu, Yu Hamady, Mohamad Xu, Xiao Yun Bioengineering (Basel) Review Thoracic endovascular aortic repair (TEVAR) of aortic aneurysms and dissections involving the arch has evolved over the last two decades. Compared to conventional surgical methods, endovascular repair offers a less invasive treatment option with lower risk and faster recovery. Endografts used in TEVAR vary in design depending on the procedure and application. Novel endografts (e.g., branched stent-graft) were developed to ensure perfusion of blood to the supra-aortic vessels, but their haemodynamic performance and long-term durability have not been adequately studied. This review focuses on the use of computational modelling to study haemodynamics in commercially available endografts designed for complex aortic arch repair. First, we summarise the currently adopted workflow for computational fluid dynamics (CFD) modelling, including geometry reconstruction, boundary conditions, flow models, and haemodynamic metrics of interest. This is followed by a review of recently (2010-present) published CFD studies on complex aortic arch repair, using both idealized and patient-specific models. Finally, we introduce some of the promising techniques that can be potentially applied to predict post-operative outcomes. MDPI 2022-10-18 /pmc/articles/PMC9598215/ /pubmed/36290541 http://dx.doi.org/10.3390/bioengineering9100573 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sengupta, Sampad
Zhu, Yu
Hamady, Mohamad
Xu, Xiao Yun
Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair
title Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair
title_full Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair
title_fullStr Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair
title_full_unstemmed Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair
title_short Evaluating the Haemodynamic Performance of Endografts for Complex Aortic Arch Repair
title_sort evaluating the haemodynamic performance of endografts for complex aortic arch repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598215/
https://www.ncbi.nlm.nih.gov/pubmed/36290541
http://dx.doi.org/10.3390/bioengineering9100573
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