Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response

Retinal ganglion cells (RGCs), the projection neurons of the eye, are irreversibly lost once the optic nerve is injured, which is a critical mechanism of glaucoma. Mobile zinc (Zn(2+)) levels rapidly increase in retinal interneuron amacrine cells and Zn(2+) is then transferred to RGCs via the Zn(2+)...

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Detalles Bibliográficos
Autores principales: Tang, Jiahui, Liu, Zhe, Han, Jiaxu, Xue, Jingfei, Liu, Liyan, Lin, Jicheng, Wu, Caiqing, Zhang, Qi, Wu, Siting, Liu, Canying, Huang, Haishun, Fu, Yuanyuan, Li, Min, Zhuo, Yehong, Li, Yiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598227/
https://www.ncbi.nlm.nih.gov/pubmed/36290724
http://dx.doi.org/10.3390/antiox11102001

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