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Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulation

Transmembrane protease serine 2 (TMPRSS2) is a membrane-bound protease expressed in many human epithelial tissues, including the airway and lung. TMPRSS2-mediated cleavage of viral spike protein is a key mechanism in severe acute respiratory syndrome coronavirus 2 activation and host cell entry. To...

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Detalles Bibliográficos
Autores principales:	Zhang, Yikai, Sun, Shijin, Du, Chunyu, Hu, Kaixuan, Zhang, Ce, Liu, Meng, Wu, Qingyu, Dong, Ningzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598255/ https://www.ncbi.nlm.nih.gov/pubmed/36309092 http://dx.doi.org/10.1016/j.jbc.2022.102643

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