A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients

Understanding antibiotic concentration-time profiles in the central nervous system (CNS) is crucial to treat severe life-threatening CNS infections, such as nosocomial ventriculitis or meningitis. Yet CNS distribution is likely to be altered in patients with brain damage and infection/inflammation....

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Detalles Bibliográficos
Autores principales: Chauzy, Alexia, Bouchène, Salim, Aranzana-Climent, Vincent, Clarhaut, Jonathan, Adier, Christophe, Grégoire, Nicolas, Couet, William, Dahyot-Fizelier, Claire, Marchand, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598284/
https://www.ncbi.nlm.nih.gov/pubmed/36289950
http://dx.doi.org/10.3390/antibiotics11101293

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