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Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laborato...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598335/ https://www.ncbi.nlm.nih.gov/pubmed/36289663 http://dx.doi.org/10.3390/biomedicines10102401 |
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author | Caputi, Luigi Boncoraglio, Giorgio B. Bernardi, Gaetano Ciusani, Emilio Dantes, Marcello de Liso, Federica Erbetta, Alessandra Marucci, Gianluca Matinato, Caterina Corsini, Elena |
author_facet | Caputi, Luigi Boncoraglio, Giorgio B. Bernardi, Gaetano Ciusani, Emilio Dantes, Marcello de Liso, Federica Erbetta, Alessandra Marucci, Gianluca Matinato, Caterina Corsini, Elena |
author_sort | Caputi, Luigi |
collection | PubMed |
description | Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laboratory marker. Cerebrospinal fluid and serum anti-cyclic citrullinated peptide (CCP) IgG were measured, and the intrathecal synthesis of anti-CCP antibodies (anti-CCP antibody index) was calculated using the hyperbolic function. The anti-CCP antibody index was positive in both cases at first diagnosis and progressively decreased after treatments. Together with clinical and radiological criteria, the calculation of the anti-CCP intrathecal synthesis, more than the simple measurement of serum or cerebrospinal fluid anti-CCP antibody titers, may represent a useful tool for RM diagnosis and, possibly, for treatment response. |
format | Online Article Text |
id | pubmed-9598335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95983352022-10-27 Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis Caputi, Luigi Boncoraglio, Giorgio B. Bernardi, Gaetano Ciusani, Emilio Dantes, Marcello de Liso, Federica Erbetta, Alessandra Marucci, Gianluca Matinato, Caterina Corsini, Elena Biomedicines Communication Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laboratory marker. Cerebrospinal fluid and serum anti-cyclic citrullinated peptide (CCP) IgG were measured, and the intrathecal synthesis of anti-CCP antibodies (anti-CCP antibody index) was calculated using the hyperbolic function. The anti-CCP antibody index was positive in both cases at first diagnosis and progressively decreased after treatments. Together with clinical and radiological criteria, the calculation of the anti-CCP intrathecal synthesis, more than the simple measurement of serum or cerebrospinal fluid anti-CCP antibody titers, may represent a useful tool for RM diagnosis and, possibly, for treatment response. MDPI 2022-09-26 /pmc/articles/PMC9598335/ /pubmed/36289663 http://dx.doi.org/10.3390/biomedicines10102401 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Caputi, Luigi Boncoraglio, Giorgio B. Bernardi, Gaetano Ciusani, Emilio Dantes, Marcello de Liso, Federica Erbetta, Alessandra Marucci, Gianluca Matinato, Caterina Corsini, Elena Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis |
title | Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis |
title_full | Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis |
title_fullStr | Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis |
title_full_unstemmed | Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis |
title_short | Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis |
title_sort | anti-cyclic citrullinated peptide antibody index in the cerebrospinal fluid for the diagnosis and monitoring of rheumatoid meningitis |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598335/ https://www.ncbi.nlm.nih.gov/pubmed/36289663 http://dx.doi.org/10.3390/biomedicines10102401 |
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