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Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis

Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laborato...

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Autores principales: Caputi, Luigi, Boncoraglio, Giorgio B., Bernardi, Gaetano, Ciusani, Emilio, Dantes, Marcello, de Liso, Federica, Erbetta, Alessandra, Marucci, Gianluca, Matinato, Caterina, Corsini, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598335/
https://www.ncbi.nlm.nih.gov/pubmed/36289663
http://dx.doi.org/10.3390/biomedicines10102401
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author Caputi, Luigi
Boncoraglio, Giorgio B.
Bernardi, Gaetano
Ciusani, Emilio
Dantes, Marcello
de Liso, Federica
Erbetta, Alessandra
Marucci, Gianluca
Matinato, Caterina
Corsini, Elena
author_facet Caputi, Luigi
Boncoraglio, Giorgio B.
Bernardi, Gaetano
Ciusani, Emilio
Dantes, Marcello
de Liso, Federica
Erbetta, Alessandra
Marucci, Gianluca
Matinato, Caterina
Corsini, Elena
author_sort Caputi, Luigi
collection PubMed
description Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laboratory marker. Cerebrospinal fluid and serum anti-cyclic citrullinated peptide (CCP) IgG were measured, and the intrathecal synthesis of anti-CCP antibodies (anti-CCP antibody index) was calculated using the hyperbolic function. The anti-CCP antibody index was positive in both cases at first diagnosis and progressively decreased after treatments. Together with clinical and radiological criteria, the calculation of the anti-CCP intrathecal synthesis, more than the simple measurement of serum or cerebrospinal fluid anti-CCP antibody titers, may represent a useful tool for RM diagnosis and, possibly, for treatment response.
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spelling pubmed-95983352022-10-27 Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis Caputi, Luigi Boncoraglio, Giorgio B. Bernardi, Gaetano Ciusani, Emilio Dantes, Marcello de Liso, Federica Erbetta, Alessandra Marucci, Gianluca Matinato, Caterina Corsini, Elena Biomedicines Communication Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laboratory marker. Cerebrospinal fluid and serum anti-cyclic citrullinated peptide (CCP) IgG were measured, and the intrathecal synthesis of anti-CCP antibodies (anti-CCP antibody index) was calculated using the hyperbolic function. The anti-CCP antibody index was positive in both cases at first diagnosis and progressively decreased after treatments. Together with clinical and radiological criteria, the calculation of the anti-CCP intrathecal synthesis, more than the simple measurement of serum or cerebrospinal fluid anti-CCP antibody titers, may represent a useful tool for RM diagnosis and, possibly, for treatment response. MDPI 2022-09-26 /pmc/articles/PMC9598335/ /pubmed/36289663 http://dx.doi.org/10.3390/biomedicines10102401 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Caputi, Luigi
Boncoraglio, Giorgio B.
Bernardi, Gaetano
Ciusani, Emilio
Dantes, Marcello
de Liso, Federica
Erbetta, Alessandra
Marucci, Gianluca
Matinato, Caterina
Corsini, Elena
Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
title Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
title_full Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
title_fullStr Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
title_full_unstemmed Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
title_short Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis
title_sort anti-cyclic citrullinated peptide antibody index in the cerebrospinal fluid for the diagnosis and monitoring of rheumatoid meningitis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598335/
https://www.ncbi.nlm.nih.gov/pubmed/36289663
http://dx.doi.org/10.3390/biomedicines10102401
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