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Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification

To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subr...

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Autores principales: Muth, Daniel Rudolf, Toro, Mario Damiano, Bajka, Anahita, Jonak, Kamil, Rieder, Roman, Kohler, Myrtha Magdalena, Gunzinger, Jeanne Martine, Souied, Eric H., Engelbert, Michael, Freund, K. Bailey, Zweifel, Sandrine Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598373/
https://www.ncbi.nlm.nih.gov/pubmed/36289632
http://dx.doi.org/10.3390/biomedicines10102370
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author Muth, Daniel Rudolf
Toro, Mario Damiano
Bajka, Anahita
Jonak, Kamil
Rieder, Roman
Kohler, Myrtha Magdalena
Gunzinger, Jeanne Martine
Souied, Eric H.
Engelbert, Michael
Freund, K. Bailey
Zweifel, Sandrine Anne
author_facet Muth, Daniel Rudolf
Toro, Mario Damiano
Bajka, Anahita
Jonak, Kamil
Rieder, Roman
Kohler, Myrtha Magdalena
Gunzinger, Jeanne Martine
Souied, Eric H.
Engelbert, Michael
Freund, K. Bailey
Zweifel, Sandrine Anne
author_sort Muth, Daniel Rudolf
collection PubMed
description To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline. Results: One eye of each eligible patient was included (n = 191). Patients with predominant SDDs had an increased adjusted odds ratio (aOR) for MNV 2 (23.4453, p = 0.0025) and any type of MNV 3 (8.7374, p < 0.0001). Patients with MNV 1/2 had an aOR for predominant SDDs (0.3284, p = 0.0084). Patients with MNV1 showed an aOR for SDDs (0.0357, p < 0.0001). Eyes with SDDs only without other drusen types showed an aOR for MNV 2 (9.2945, p < 0.0001). Conclusions: SDDs represent a common phenotypic characteristic in AMD eyes with treatment-naïve MNV. The aOR for eyes with predominant SDDs to develop MNV 2 and MNV 3 was much higher, possibly due to their location in the subretinal space. The predominant druse type may help to predict which type of MNV will develop during the course of AMD.
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spelling pubmed-95983732022-10-27 Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification Muth, Daniel Rudolf Toro, Mario Damiano Bajka, Anahita Jonak, Kamil Rieder, Roman Kohler, Myrtha Magdalena Gunzinger, Jeanne Martine Souied, Eric H. Engelbert, Michael Freund, K. Bailey Zweifel, Sandrine Anne Biomedicines Article To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline. Results: One eye of each eligible patient was included (n = 191). Patients with predominant SDDs had an increased adjusted odds ratio (aOR) for MNV 2 (23.4453, p = 0.0025) and any type of MNV 3 (8.7374, p < 0.0001). Patients with MNV 1/2 had an aOR for predominant SDDs (0.3284, p = 0.0084). Patients with MNV1 showed an aOR for SDDs (0.0357, p < 0.0001). Eyes with SDDs only without other drusen types showed an aOR for MNV 2 (9.2945, p < 0.0001). Conclusions: SDDs represent a common phenotypic characteristic in AMD eyes with treatment-naïve MNV. The aOR for eyes with predominant SDDs to develop MNV 2 and MNV 3 was much higher, possibly due to their location in the subretinal space. The predominant druse type may help to predict which type of MNV will develop during the course of AMD. MDPI 2022-09-22 /pmc/articles/PMC9598373/ /pubmed/36289632 http://dx.doi.org/10.3390/biomedicines10102370 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muth, Daniel Rudolf
Toro, Mario Damiano
Bajka, Anahita
Jonak, Kamil
Rieder, Roman
Kohler, Myrtha Magdalena
Gunzinger, Jeanne Martine
Souied, Eric H.
Engelbert, Michael
Freund, K. Bailey
Zweifel, Sandrine Anne
Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
title Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
title_full Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
title_fullStr Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
title_full_unstemmed Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
title_short Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
title_sort correlation between macular neovascularization (mnv) type and druse type in neovascular age-related macular degeneration (amd) based on the conan classification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598373/
https://www.ncbi.nlm.nih.gov/pubmed/36289632
http://dx.doi.org/10.3390/biomedicines10102370
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