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Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report
Phages are immunogenic and may evoke an immune response following their administration. Consequently, patients undergoing phage therapy (PT) produce phage-neutralizing serum antibodies. The clinical significance of this phenomenon for the success or failure of the therapy is currently unclear. Inter...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598433/ https://www.ncbi.nlm.nih.gov/pubmed/36290015 http://dx.doi.org/10.3390/antibiotics11101358 |
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author | Łusiak-Szelachowska, Marzanna Międzybrodzki, Ryszard Rogóż, Paweł Weber-Dąbrowska, Beata Żaczek, Maciej Górski, Andrzej |
author_facet | Łusiak-Szelachowska, Marzanna Międzybrodzki, Ryszard Rogóż, Paweł Weber-Dąbrowska, Beata Żaczek, Maciej Górski, Andrzej |
author_sort | Łusiak-Szelachowska, Marzanna |
collection | PubMed |
description | Phages are immunogenic and may evoke an immune response following their administration. Consequently, patients undergoing phage therapy (PT) produce phage-neutralizing serum antibodies. The clinical significance of this phenomenon for the success or failure of the therapy is currently unclear. Interestingly, even a strong anti-phage humoral response does not exclude the success of PT. On the other hand, it cannot be ruled out that phage–antibody complexes may be trapped in tissues and organs causing injury and late complications of PT. Therefore, patients should be monitored for the presence of serum antibodies and therapy discontinued if their level is high. Our preliminary data suggest that the kinetics of the disappearance of those antibodies may vary from patient to patient and in some cases may take more than a year. |
format | Online Article Text |
id | pubmed-9598433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95984332022-10-27 Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report Łusiak-Szelachowska, Marzanna Międzybrodzki, Ryszard Rogóż, Paweł Weber-Dąbrowska, Beata Żaczek, Maciej Górski, Andrzej Antibiotics (Basel) Communication Phages are immunogenic and may evoke an immune response following their administration. Consequently, patients undergoing phage therapy (PT) produce phage-neutralizing serum antibodies. The clinical significance of this phenomenon for the success or failure of the therapy is currently unclear. Interestingly, even a strong anti-phage humoral response does not exclude the success of PT. On the other hand, it cannot be ruled out that phage–antibody complexes may be trapped in tissues and organs causing injury and late complications of PT. Therefore, patients should be monitored for the presence of serum antibodies and therapy discontinued if their level is high. Our preliminary data suggest that the kinetics of the disappearance of those antibodies may vary from patient to patient and in some cases may take more than a year. MDPI 2022-10-05 /pmc/articles/PMC9598433/ /pubmed/36290015 http://dx.doi.org/10.3390/antibiotics11101358 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Łusiak-Szelachowska, Marzanna Międzybrodzki, Ryszard Rogóż, Paweł Weber-Dąbrowska, Beata Żaczek, Maciej Górski, Andrzej Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report |
title | Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report |
title_full | Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report |
title_fullStr | Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report |
title_full_unstemmed | Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report |
title_short | Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report |
title_sort | do anti-phage antibodies persist after phage therapy? a preliminary report |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598433/ https://www.ncbi.nlm.nih.gov/pubmed/36290015 http://dx.doi.org/10.3390/antibiotics11101358 |
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