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Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation

We created an overall assessment metric using a deep learning autoencoder to directly compare clinical outcomes in a comparison of lower limb amputees using two different prosthetic devices—a mechanical knee and a microprocessor-controlled knee. Eight clinical outcomes were distilled into a single m...

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Detalles Bibliográficos
Autores principales: Tabashum, Thasina, Xiao, Ting, Jayaraman, Chandrasekaran, Mummidisetty, Chaithanya K., Jayaraman, Arun, Albert, Mark V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598529/
https://www.ncbi.nlm.nih.gov/pubmed/36290540
http://dx.doi.org/10.3390/bioengineering9100572
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author Tabashum, Thasina
Xiao, Ting
Jayaraman, Chandrasekaran
Mummidisetty, Chaithanya K.
Jayaraman, Arun
Albert, Mark V.
author_facet Tabashum, Thasina
Xiao, Ting
Jayaraman, Chandrasekaran
Mummidisetty, Chaithanya K.
Jayaraman, Arun
Albert, Mark V.
author_sort Tabashum, Thasina
collection PubMed
description We created an overall assessment metric using a deep learning autoencoder to directly compare clinical outcomes in a comparison of lower limb amputees using two different prosthetic devices—a mechanical knee and a microprocessor-controlled knee. Eight clinical outcomes were distilled into a single metric using a seven-layer deep autoencoder, with the developed metric compared to similar results from principal component analysis (PCA). The proposed methods were used on data collected from ten participants with a dysvascular transfemoral amputation recruited for a prosthetics research study. This single summary metric permitted a cross-validated reconstruction of all eight scores, accounting for 83.29% of the variance. The derived score is also linked to the overall functional ability in this limited trial population, as improvements in each base clinical score led to increases in this developed metric. There was a highly significant increase in this autoencoder-based metric when the subjects used the microprocessor-controlled knee (p < 0.001, repeated measures ANOVA). A traditional PCA metric led to a similar interpretation but captured only 67.3% of the variance. The autoencoder composite score represents a single-valued, succinct summary that can be useful for the holistic assessment of highly variable, individual scores in limited clinical datasets.
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spelling pubmed-95985292022-10-27 Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation Tabashum, Thasina Xiao, Ting Jayaraman, Chandrasekaran Mummidisetty, Chaithanya K. Jayaraman, Arun Albert, Mark V. Bioengineering (Basel) Article We created an overall assessment metric using a deep learning autoencoder to directly compare clinical outcomes in a comparison of lower limb amputees using two different prosthetic devices—a mechanical knee and a microprocessor-controlled knee. Eight clinical outcomes were distilled into a single metric using a seven-layer deep autoencoder, with the developed metric compared to similar results from principal component analysis (PCA). The proposed methods were used on data collected from ten participants with a dysvascular transfemoral amputation recruited for a prosthetics research study. This single summary metric permitted a cross-validated reconstruction of all eight scores, accounting for 83.29% of the variance. The derived score is also linked to the overall functional ability in this limited trial population, as improvements in each base clinical score led to increases in this developed metric. There was a highly significant increase in this autoencoder-based metric when the subjects used the microprocessor-controlled knee (p < 0.001, repeated measures ANOVA). A traditional PCA metric led to a similar interpretation but captured only 67.3% of the variance. The autoencoder composite score represents a single-valued, succinct summary that can be useful for the holistic assessment of highly variable, individual scores in limited clinical datasets. MDPI 2022-10-18 /pmc/articles/PMC9598529/ /pubmed/36290540 http://dx.doi.org/10.3390/bioengineering9100572 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tabashum, Thasina
Xiao, Ting
Jayaraman, Chandrasekaran
Mummidisetty, Chaithanya K.
Jayaraman, Arun
Albert, Mark V.
Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation
title Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation
title_full Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation
title_fullStr Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation
title_full_unstemmed Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation
title_short Autoencoder Composite Scoring to Evaluate Prosthetic Performance in Individuals with Lower Limb Amputation
title_sort autoencoder composite scoring to evaluate prosthetic performance in individuals with lower limb amputation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598529/
https://www.ncbi.nlm.nih.gov/pubmed/36290540
http://dx.doi.org/10.3390/bioengineering9100572
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