Cargando…

Heme Oxygenase-1 Overexpression Promotes Uveal Melanoma Progression and Is Associated with Poor Clinical Outcomes

Uveal melanoma (UM) is the most common primary intraocular tumor in adults. To date, the main strategies to counteract its progression consist of focal radiation on the tumor site and ocular enucleation. Furthermore, many UM patients develop liver metastasis within 10 years following diagnosis, even...

Descripción completa

Detalles Bibliográficos
Autores principales:	Longhitano, Lucia, Broggi, Giuseppe, Giallongo, Sebastiano, Failla, Maria, Puzzo, Lidia, Avitabile, Teresio, Tibullo, Daniele, Distefano, Alfio, Pittalà, Valeria, Reibaldi, Michele, Zanghì, Guido Nicola, Longo, Antonio, Russo, Andrea, Caltabiano, Rosario, Volti, Giovanni Li, Musso, Nicolò
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598584/ https://www.ncbi.nlm.nih.gov/pubmed/36290720 http://dx.doi.org/10.3390/antiox11101997

Ejemplares similares

Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells
por: Giallongo, Sebastiano, et al.
Publicado: (2020)

Increased Levels of miRNA-146a in Serum and Histologic Samples of Patients with Uveal Melanoma
por: Russo, Andrea, et al.
Publicado: (2016)

Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype
por: Longhitano, Lucia, et al.
Publicado: (2022)

LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network
por: Barbagallo, Cristina, et al.
Publicado: (2020)

Heme Oxygenase-1 in Central Nervous System Malignancies
por: Sferrazzo, Giuseppe, et al.
Publicado: (2020)

A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas
por: Failla, Maria, et al.
Publicado: (2022)

The non-canonical functions of the heme oxygenases
por: Vanella, Luca, et al.
Publicado: (2016)

Current molecular and clinical insights into uveal melanoma (Review)
por: Fallico, Matteo, et al.
Publicado: (2021)

Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models
por: Carota, Giuseppe, et al.
Publicado: (2022)

TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment
por: Scandura, Grazia, et al.
Publicado: (2022)

Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations
por: Foti, Pietro Valerio, et al.
Publicado: (2021)

Histopathologic and MR Imaging Appearance of Spontaneous and Radiation-Induced Necrosis in Uveal Melanomas: Initial Results
por: Foti, Pietro Valerio, et al.
Publicado: (2022)

Differential modulation and prognostic values of immune-escape genes in uveal melanoma
por: Basile, Maria Sofia, et al.
Publicado: (2019)

Uveal Melanoma Cells Elicit Retinal Pericyte Phenotypical and Biochemical Changes in an in Vitro Model of Coculture
por: Anfuso, Carmelina Daniela, et al.
Publicado: (2020)

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells
por: Tibullo, Daniele, et al.
Publicado: (2016)

Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: treatment indications and complications
por: Foti, Pietro Valerio, et al.
Publicado: (2021)

Characterization of the Pathophysiological Role of CD47 in Uveal Melanoma
por: Petralia, Maria Cristina, et al.
Publicado: (2019)

The Macro-Autophagy-Related Protein Beclin-1 Immunohistochemical Expression Correlates With Tumor Cell Type and Clinical Behavior of Uveal Melanoma
por: Broggi, Giuseppe, et al.
Publicado: (2020)

Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets
por: Basile, Maria Sofia, et al.
Publicado: (2019)

Commentary: The apolipoprotein A-I mimetic peptide, D-4F, restrains neointimal formation through heme oxygenase-1 up-regulation
por: Li Volti, Giovanni, et al.
Publicado: (2017)

MicroRNAs in vitreus humor from patients with ocular diseases
por: Ragusa, Marco, et al.
Publicado: (2013)

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells
por: Consoli, Valeria, et al.
Publicado: (2022)

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
por: Longhitano, Lucia, et al.
Publicado: (2017)

Role of 17β-Estradiol on Cell Proliferation and Mitochondrial Fitness in Glioblastoma Cells
por: Castracani, Carlo Castruccio, et al.
Publicado: (2020)

Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death
por: Raffaele, Marco, et al.
Publicado: (2019)

Therapeutic Efficacy of Stem Cells Transplantation in Diabetes: Role of Heme Oxygenase
por: Raffaele, Marco, et al.
Publicado: (2016)

The Pleiotropic Effects of Fumarate: From Mitochondrial Respiration to Epigenetic Rewiring and DNA Repair Mechanisms
por: Giallongo, Sebastiano, et al.
Publicado: (2023)

Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma
por: Longhitano, Lucia, et al.
Publicado: (2022)

Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance
por: D’Aprile, Simona, et al.
Publicado: (2023)

(+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis
por: Longhitano, Lucia, et al.
Publicado: (2023)

Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity
por: Fallica, Antonino N., et al.
Publicado: (2021)

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure
por: Sorrenti, Valeria, et al.
Publicado: (2020)

The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated
por: Suárez-Rojas, Irene, et al.
Publicado: (2023)

Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions
por: Fagone, Paolo, et al.
Publicado: (2023)

Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2
por: Longhitano, Lucia, et al.
Publicado: (2020)

Heme Oxygenase-1 Deficiency
por: Renji, Soumya, et al.
Publicado: (2021)

Genetics and RNA Regulation of Uveal Melanoma
por: Barbagallo, Cristina, et al.
Publicado: (2023)

Identification of novel chemotherapeutic strategies for metastatic uveal melanoma
por: Fagone, Paolo, et al.
Publicado: (2017)

Scleral Buckling: A Review of Clinical Aspects and Current Concepts
por: Fallico, Matteo, et al.
Publicado: (2022)

Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats
por: Sorrenti, Valeria, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ustd1s6ba4f1362epbbak5d5ka