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Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity

Non-alcoholic fatty liver disease (NAFLD) is associated with several other metabolic disorders, which are typically pro-inflammatory states. Body fat content is an important marker of metabolic health and abdominal fat is associated with harmful cardiometabolic outcomes. We aimed to evaluate the ass...

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Autores principales: Borges-Canha, Marta, Neves, João Sérgio, Silva, Maria Manuel, Mendonça, Fernando, Moreno, Telma, Ribeiro, Sara, Correa, João, Vale, Catarina, Gonçalves, Juliana, Urbano Ferreira, Helena, Gil-Santos, Sara, Guerreiro, Vanessa, Sande, Ana, B. Souto, Selma, Pedro, Jorge, Freitas, Paula, Carvalho, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598594/
https://www.ncbi.nlm.nih.gov/pubmed/36289677
http://dx.doi.org/10.3390/biomedicines10102416
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author Borges-Canha, Marta
Neves, João Sérgio
Silva, Maria Manuel
Mendonça, Fernando
Moreno, Telma
Ribeiro, Sara
Correa, João
Vale, Catarina
Gonçalves, Juliana
Urbano Ferreira, Helena
Gil-Santos, Sara
Guerreiro, Vanessa
Sande, Ana
B. Souto, Selma
Pedro, Jorge
Freitas, Paula
Carvalho, Davide
author_facet Borges-Canha, Marta
Neves, João Sérgio
Silva, Maria Manuel
Mendonça, Fernando
Moreno, Telma
Ribeiro, Sara
Correa, João
Vale, Catarina
Gonçalves, Juliana
Urbano Ferreira, Helena
Gil-Santos, Sara
Guerreiro, Vanessa
Sande, Ana
B. Souto, Selma
Pedro, Jorge
Freitas, Paula
Carvalho, Davide
author_sort Borges-Canha, Marta
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is associated with several other metabolic disorders, which are typically pro-inflammatory states. Body fat content is an important marker of metabolic health and abdominal fat is associated with harmful cardiometabolic outcomes. We aimed to evaluate the association between the risk of NAFLD (through Fatty Liver Index (FLI), and BMI, AST/ALT ratio, and presence of diabetes (BARD)), and anthropometric parameters, predictors of metabolic status, in patients with morbid obesity, and to evaluate the association of FLI and BARD scores with pro-inflammatory markers. We have retrospectively studied patients with morbid obesity followed in our center. In total, 2184 participants were included, with an average age of 42.8 ± 10.6 years, 84.5% being females. We report a positive association of FLI with waist circumference (β = 0.10 [0.09 to 0.11], p < 0.01) and waist-to-hip ratio (β = 8.68 [6.85 to 10.52, p < 0.01]), even after adjusting for age, sex, body mass index, diabetes, and dyslipidemia (p < 0.01 for both adjusted models). The associations of BARD with anthropometric measures were significant only in the non-adjusted model. There was a positive association between both FLI and BARD and C-reactive protein. Our results point towards a positive association between waist-to-hip ratio and the risk of hepatic steatosis, and between pro-inflammatory markers and both hepatic steatosis and fibrosis.
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spelling pubmed-95985942022-10-27 Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity Borges-Canha, Marta Neves, João Sérgio Silva, Maria Manuel Mendonça, Fernando Moreno, Telma Ribeiro, Sara Correa, João Vale, Catarina Gonçalves, Juliana Urbano Ferreira, Helena Gil-Santos, Sara Guerreiro, Vanessa Sande, Ana B. Souto, Selma Pedro, Jorge Freitas, Paula Carvalho, Davide Biomedicines Article Non-alcoholic fatty liver disease (NAFLD) is associated with several other metabolic disorders, which are typically pro-inflammatory states. Body fat content is an important marker of metabolic health and abdominal fat is associated with harmful cardiometabolic outcomes. We aimed to evaluate the association between the risk of NAFLD (through Fatty Liver Index (FLI), and BMI, AST/ALT ratio, and presence of diabetes (BARD)), and anthropometric parameters, predictors of metabolic status, in patients with morbid obesity, and to evaluate the association of FLI and BARD scores with pro-inflammatory markers. We have retrospectively studied patients with morbid obesity followed in our center. In total, 2184 participants were included, with an average age of 42.8 ± 10.6 years, 84.5% being females. We report a positive association of FLI with waist circumference (β = 0.10 [0.09 to 0.11], p < 0.01) and waist-to-hip ratio (β = 8.68 [6.85 to 10.52, p < 0.01]), even after adjusting for age, sex, body mass index, diabetes, and dyslipidemia (p < 0.01 for both adjusted models). The associations of BARD with anthropometric measures were significant only in the non-adjusted model. There was a positive association between both FLI and BARD and C-reactive protein. Our results point towards a positive association between waist-to-hip ratio and the risk of hepatic steatosis, and between pro-inflammatory markers and both hepatic steatosis and fibrosis. MDPI 2022-09-27 /pmc/articles/PMC9598594/ /pubmed/36289677 http://dx.doi.org/10.3390/biomedicines10102416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borges-Canha, Marta
Neves, João Sérgio
Silva, Maria Manuel
Mendonça, Fernando
Moreno, Telma
Ribeiro, Sara
Correa, João
Vale, Catarina
Gonçalves, Juliana
Urbano Ferreira, Helena
Gil-Santos, Sara
Guerreiro, Vanessa
Sande, Ana
B. Souto, Selma
Pedro, Jorge
Freitas, Paula
Carvalho, Davide
Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity
title Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity
title_full Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity
title_fullStr Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity
title_full_unstemmed Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity
title_short Waist-to-Hip Ratio and Inflammatory Parameters Are Associated with Risk of Non-Alcoholic Fatty Liver Disease in Patients with Morbid Obesity
title_sort waist-to-hip ratio and inflammatory parameters are associated with risk of non-alcoholic fatty liver disease in patients with morbid obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598594/
https://www.ncbi.nlm.nih.gov/pubmed/36289677
http://dx.doi.org/10.3390/biomedicines10102416
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