Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome

Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 μg/cm(3) was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ce...

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Detalles Bibliográficos
Autores principales: Valiulin, Sergey V., Onischuk, Andrei A., Baklanov, Anatoly M., An’kov, Sergey V., Dubtsov, Sergey N., Alekseev, Alexander A., Shkil, Nikolay N., Nefedova, Ekaterina V., Plokhotnichenko, Maria E., Tolstikova, Tatyana G., Dolgov, Arseniy M., Dultseva, Galina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598611/
https://www.ncbi.nlm.nih.gov/pubmed/36289963
http://dx.doi.org/10.3390/antibiotics11101305
Descripción
Sumario:Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 μg/cm(3) was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ceftriaxone concentration in blood serum and its mass in the lungs of mice were measured as a function of time using high-performance liquid chromatography. The body-delivered dose was within the range 3–5 mg/kg. The antibacterial effect of aerosolized ceftriaxone was investigated for mice infected with Klebsiella pneumoniae 82 and Staphylococcus aureus ATCC 25 953. The survival rate for infected mice after the treatment with ceftriaxone aerosol revealed the high antibacterial efficiency of this kind of treatment.

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