Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome

Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 μg/cm(3) was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ce...

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Autores principales: Valiulin, Sergey V., Onischuk, Andrei A., Baklanov, Anatoly M., An’kov, Sergey V., Dubtsov, Sergey N., Alekseev, Alexander A., Shkil, Nikolay N., Nefedova, Ekaterina V., Plokhotnichenko, Maria E., Tolstikova, Tatyana G., Dolgov, Arseniy M., Dultseva, Galina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598611/
https://www.ncbi.nlm.nih.gov/pubmed/36289963
http://dx.doi.org/10.3390/antibiotics11101305
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author Valiulin, Sergey V.
Onischuk, Andrei A.
Baklanov, Anatoly M.
An’kov, Sergey V.
Dubtsov, Sergey N.
Alekseev, Alexander A.
Shkil, Nikolay N.
Nefedova, Ekaterina V.
Plokhotnichenko, Maria E.
Tolstikova, Tatyana G.
Dolgov, Arseniy M.
Dultseva, Galina G.
author_facet Valiulin, Sergey V.
Onischuk, Andrei A.
Baklanov, Anatoly M.
An’kov, Sergey V.
Dubtsov, Sergey N.
Alekseev, Alexander A.
Shkil, Nikolay N.
Nefedova, Ekaterina V.
Plokhotnichenko, Maria E.
Tolstikova, Tatyana G.
Dolgov, Arseniy M.
Dultseva, Galina G.
author_sort Valiulin, Sergey V.
collection PubMed
description Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 μg/cm(3) was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ceftriaxone concentration in blood serum and its mass in the lungs of mice were measured as a function of time using high-performance liquid chromatography. The body-delivered dose was within the range 3–5 mg/kg. The antibacterial effect of aerosolized ceftriaxone was investigated for mice infected with Klebsiella pneumoniae 82 and Staphylococcus aureus ATCC 25 953. The survival rate for infected mice after the treatment with ceftriaxone aerosol revealed the high antibacterial efficiency of this kind of treatment.
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spelling pubmed-95986112022-10-27 Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome Valiulin, Sergey V. Onischuk, Andrei A. Baklanov, Anatoly M. An’kov, Sergey V. Dubtsov, Sergey N. Alekseev, Alexander A. Shkil, Nikolay N. Nefedova, Ekaterina V. Plokhotnichenko, Maria E. Tolstikova, Tatyana G. Dolgov, Arseniy M. Dultseva, Galina G. Antibiotics (Basel) Article Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 μg/cm(3) was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ceftriaxone concentration in blood serum and its mass in the lungs of mice were measured as a function of time using high-performance liquid chromatography. The body-delivered dose was within the range 3–5 mg/kg. The antibacterial effect of aerosolized ceftriaxone was investigated for mice infected with Klebsiella pneumoniae 82 and Staphylococcus aureus ATCC 25 953. The survival rate for infected mice after the treatment with ceftriaxone aerosol revealed the high antibacterial efficiency of this kind of treatment. MDPI 2022-09-25 /pmc/articles/PMC9598611/ /pubmed/36289963 http://dx.doi.org/10.3390/antibiotics11101305 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valiulin, Sergey V.
Onischuk, Andrei A.
Baklanov, Anatoly M.
An’kov, Sergey V.
Dubtsov, Sergey N.
Alekseev, Alexander A.
Shkil, Nikolay N.
Nefedova, Ekaterina V.
Plokhotnichenko, Maria E.
Tolstikova, Tatyana G.
Dolgov, Arseniy M.
Dultseva, Galina G.
Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
title Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
title_full Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
title_fullStr Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
title_full_unstemmed Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
title_short Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome
title_sort aerosol inhalation delivery of ceftriaxone in mice: generation procedure, pharmacokinetics, and therapeutic outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598611/
https://www.ncbi.nlm.nih.gov/pubmed/36289963
http://dx.doi.org/10.3390/antibiotics11101305
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