Culturing of Cardiac Fibroblasts in Engineered Heart Matrix Reduces Myofibroblast Differentiation but Maintains Their Response to Cyclic Stretch and Transforming Growth Factor β1

Isolation and culturing of cardiac fibroblasts (CF) induces rapid differentiation toward a myofibroblast phenotype, which is partly mediated by the high substrate stiffness of the culture plates. In the present study, a 3D model of Engineered Heart Matrix (EHM) of physiological stiffness (Youngs mod...

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Detalles Bibliográficos
Autores principales: Ploeg, Meike C., Munts, Chantal, Seddiqi, Tayeba, ten Brink, Tim J. L., Breemhaar, Jonathan, Moroni, Lorenzo, Prinzen, Frits. W., van Nieuwenhoven, Frans. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598692/
https://www.ncbi.nlm.nih.gov/pubmed/36290519
http://dx.doi.org/10.3390/bioengineering9100551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598692/
https://www.ncbi.nlm.nih.gov/pubmed/36290519
http://dx.doi.org/10.3390/bioengineering9100551

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