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Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine

Brain dopamine, in relation to the limbic system, is involved in cognition and emotion. These functions are asymmetrically processed. Hypertension not only alters such functions but also their asymmetric brain pattern as well as their bilateral pattern of neurovisceral integration. The central and p...

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Autores principales: Banegas, Inmaculada, Prieto, Isabel, Segarra, Ana Belén, Vives, Francisco, Martínez-Cañamero, Magdalena, Durán, Raquel, Luna, Juan de Dios, Domínguez-Vías, Germán, Ramírez-Sánchez, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598709/
https://www.ncbi.nlm.nih.gov/pubmed/36289718
http://dx.doi.org/10.3390/biomedicines10102457
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author Banegas, Inmaculada
Prieto, Isabel
Segarra, Ana Belén
Vives, Francisco
Martínez-Cañamero, Magdalena
Durán, Raquel
Luna, Juan de Dios
Domínguez-Vías, Germán
Ramírez-Sánchez, Manuel
author_facet Banegas, Inmaculada
Prieto, Isabel
Segarra, Ana Belén
Vives, Francisco
Martínez-Cañamero, Magdalena
Durán, Raquel
Luna, Juan de Dios
Domínguez-Vías, Germán
Ramírez-Sánchez, Manuel
author_sort Banegas, Inmaculada
collection PubMed
description Brain dopamine, in relation to the limbic system, is involved in cognition and emotion. These functions are asymmetrically processed. Hypertension not only alters such functions but also their asymmetric brain pattern as well as their bilateral pattern of neurovisceral integration. The central and peripheral renin-angiotensin systems, particularly the aminopeptidases involved in its enzymatic cascade, play an important role in blood pressure control. In the present study, we report how these aminopeptidases from left and right cortico-limbic locations, plasma and systolic blood pressure interact among them in spontaneously hypertensive rats (SHR) unilaterally depleted of dopamine. The study comprises left and right sham and left and right lesioned (dopamine-depleted) rats as research groups. Results revealed important differences in the bilateral behavior comparing sham left versus sham right, lesioned left versus lesioned right, and sham versus lesioned animals. Results also suggest an important role for the asymmetrical functioning of the amygdala in cardiovascular control and an asymmetrical behavior in the interaction between the medial prefrontal cortex, hippocampus and amygdala with plasma, depending on the left or right depletion of dopamine. Compared with previous results of a similar study in Wistar-Kyoto (WKY) normotensive rats, the asymmetrical behaviors differ significantly between both WKY and SHR strains.
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spelling pubmed-95987092022-10-27 Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine Banegas, Inmaculada Prieto, Isabel Segarra, Ana Belén Vives, Francisco Martínez-Cañamero, Magdalena Durán, Raquel Luna, Juan de Dios Domínguez-Vías, Germán Ramírez-Sánchez, Manuel Biomedicines Article Brain dopamine, in relation to the limbic system, is involved in cognition and emotion. These functions are asymmetrically processed. Hypertension not only alters such functions but also their asymmetric brain pattern as well as their bilateral pattern of neurovisceral integration. The central and peripheral renin-angiotensin systems, particularly the aminopeptidases involved in its enzymatic cascade, play an important role in blood pressure control. In the present study, we report how these aminopeptidases from left and right cortico-limbic locations, plasma and systolic blood pressure interact among them in spontaneously hypertensive rats (SHR) unilaterally depleted of dopamine. The study comprises left and right sham and left and right lesioned (dopamine-depleted) rats as research groups. Results revealed important differences in the bilateral behavior comparing sham left versus sham right, lesioned left versus lesioned right, and sham versus lesioned animals. Results also suggest an important role for the asymmetrical functioning of the amygdala in cardiovascular control and an asymmetrical behavior in the interaction between the medial prefrontal cortex, hippocampus and amygdala with plasma, depending on the left or right depletion of dopamine. Compared with previous results of a similar study in Wistar-Kyoto (WKY) normotensive rats, the asymmetrical behaviors differ significantly between both WKY and SHR strains. MDPI 2022-10-01 /pmc/articles/PMC9598709/ /pubmed/36289718 http://dx.doi.org/10.3390/biomedicines10102457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banegas, Inmaculada
Prieto, Isabel
Segarra, Ana Belén
Vives, Francisco
Martínez-Cañamero, Magdalena
Durán, Raquel
Luna, Juan de Dios
Domínguez-Vías, Germán
Ramírez-Sánchez, Manuel
Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
title Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
title_full Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
title_fullStr Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
title_full_unstemmed Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
title_short Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
title_sort aminopeptidase activities interact asymmetrically between brain, plasma and systolic blood pressure in hypertensive rats unilaterally depleted of dopamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598709/
https://www.ncbi.nlm.nih.gov/pubmed/36289718
http://dx.doi.org/10.3390/biomedicines10102457
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