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Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time

COVID-19 has attracted worldwide attention ever since the first case was identified in Wuhan (China) in December 2019 and was classified, at a later time, as a public health emergency of international concern in January 2020 and as a pandemic in March 2020. The interstitial pneumonia caused by COVID...

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Autores principales: Maggialetti, Nicola, Piemonte, Stefano, Sperti, Emanuela, Inchingolo, Francesco, Greco, Sabrina, Lucarelli, Nicola Maria, De Chirico, Pierluigi, Lofino, Stefano, Coppola, Federica, Catacchio, Claudia, Gravili, Anna Maria, Sardaro, Angela, Stabile Ianora, Amato Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598729/
https://www.ncbi.nlm.nih.gov/pubmed/36289754
http://dx.doi.org/10.3390/biomedicines10102493
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author Maggialetti, Nicola
Piemonte, Stefano
Sperti, Emanuela
Inchingolo, Francesco
Greco, Sabrina
Lucarelli, Nicola Maria
De Chirico, Pierluigi
Lofino, Stefano
Coppola, Federica
Catacchio, Claudia
Gravili, Anna Maria
Sardaro, Angela
Stabile Ianora, Amato Antonio
author_facet Maggialetti, Nicola
Piemonte, Stefano
Sperti, Emanuela
Inchingolo, Francesco
Greco, Sabrina
Lucarelli, Nicola Maria
De Chirico, Pierluigi
Lofino, Stefano
Coppola, Federica
Catacchio, Claudia
Gravili, Anna Maria
Sardaro, Angela
Stabile Ianora, Amato Antonio
author_sort Maggialetti, Nicola
collection PubMed
description COVID-19 has attracted worldwide attention ever since the first case was identified in Wuhan (China) in December 2019 and was classified, at a later time, as a public health emergency of international concern in January 2020 and as a pandemic in March 2020. The interstitial pneumonia caused by COVID-19 often requires mechanical ventilation, which can lead to pulmonary barotrauma. We assessed the relationship between pneumonia severity and the development of barotrauma in COVID-19-positive patients mechanically ventilated in an intensive care unit; we therefore analyzed the prevalence of iatrogenic barotrauma and its trends over time during the pandemic in COVID-19-positive patients undergoing mechanical ventilation compared to COVID-19-negative patients, making a distinction between different types of ventilation (invasive mechanical ventilation vs. noninvasive mechanical ventilation). We compared CT findings of pneumomediastinum and pneumothorax in 104 COVID-19-positive patients hospitalized in an intensive care unit and 101 COVID-19-negative patients undergoing mechanical ventilation in the period between October 2020 and December 2021. The severity of pneumonia was not directly correlated with the development of barotrauma. Furthermore, a higher prevalence of complications due to barotrauma was observed in the group of mechanically ventilated COVID-19-postive patients vs. COVID-19-negative patients. A higher rate of barotrauma was observed in subgroups of COVID-19-positive patients undergoing mechanical ventilation compared to those treated with invasive mechanical ventilation. The prevalence of barotrauma in COVID 19-positive patients showed a decreasing trend over the period under review. CT remains an essential tool in the early detection, diagnosis, and monitoring of the clinical course of SARS-CoV2 pneumonia; in evaluating the disease severity; and in the assessment of iatrogenic complications such as barotrauma pathology.
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spelling pubmed-95987292022-10-27 Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time Maggialetti, Nicola Piemonte, Stefano Sperti, Emanuela Inchingolo, Francesco Greco, Sabrina Lucarelli, Nicola Maria De Chirico, Pierluigi Lofino, Stefano Coppola, Federica Catacchio, Claudia Gravili, Anna Maria Sardaro, Angela Stabile Ianora, Amato Antonio Biomedicines Article COVID-19 has attracted worldwide attention ever since the first case was identified in Wuhan (China) in December 2019 and was classified, at a later time, as a public health emergency of international concern in January 2020 and as a pandemic in March 2020. The interstitial pneumonia caused by COVID-19 often requires mechanical ventilation, which can lead to pulmonary barotrauma. We assessed the relationship between pneumonia severity and the development of barotrauma in COVID-19-positive patients mechanically ventilated in an intensive care unit; we therefore analyzed the prevalence of iatrogenic barotrauma and its trends over time during the pandemic in COVID-19-positive patients undergoing mechanical ventilation compared to COVID-19-negative patients, making a distinction between different types of ventilation (invasive mechanical ventilation vs. noninvasive mechanical ventilation). We compared CT findings of pneumomediastinum and pneumothorax in 104 COVID-19-positive patients hospitalized in an intensive care unit and 101 COVID-19-negative patients undergoing mechanical ventilation in the period between October 2020 and December 2021. The severity of pneumonia was not directly correlated with the development of barotrauma. Furthermore, a higher prevalence of complications due to barotrauma was observed in the group of mechanically ventilated COVID-19-postive patients vs. COVID-19-negative patients. A higher rate of barotrauma was observed in subgroups of COVID-19-positive patients undergoing mechanical ventilation compared to those treated with invasive mechanical ventilation. The prevalence of barotrauma in COVID 19-positive patients showed a decreasing trend over the period under review. CT remains an essential tool in the early detection, diagnosis, and monitoring of the clinical course of SARS-CoV2 pneumonia; in evaluating the disease severity; and in the assessment of iatrogenic complications such as barotrauma pathology. MDPI 2022-10-06 /pmc/articles/PMC9598729/ /pubmed/36289754 http://dx.doi.org/10.3390/biomedicines10102493 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maggialetti, Nicola
Piemonte, Stefano
Sperti, Emanuela
Inchingolo, Francesco
Greco, Sabrina
Lucarelli, Nicola Maria
De Chirico, Pierluigi
Lofino, Stefano
Coppola, Federica
Catacchio, Claudia
Gravili, Anna Maria
Sardaro, Angela
Stabile Ianora, Amato Antonio
Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time
title Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time
title_full Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time
title_fullStr Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time
title_full_unstemmed Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time
title_short Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time
title_sort iatrogenic barotrauma in covid-19-positive patients: is it related to the pneumonia severity? prevalence and trends of this complication over time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598729/
https://www.ncbi.nlm.nih.gov/pubmed/36289754
http://dx.doi.org/10.3390/biomedicines10102493
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