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Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598742/ https://www.ncbi.nlm.nih.gov/pubmed/36289652 http://dx.doi.org/10.3390/biomedicines10102390 |
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author | Cennamo, Gilda Montorio, Daniela Ausiello, Francesco Pio Magno, Luigifilippo Iodice, Rosa Mazzucco, Alberto Iuzzolino, Valentina Virginia Senerchia, Gianmaria Brescia Morra, Vincenzo Nolano, Maria Costagliola, Ciro Dubbioso, Raffaele |
author_facet | Cennamo, Gilda Montorio, Daniela Ausiello, Francesco Pio Magno, Luigifilippo Iodice, Rosa Mazzucco, Alberto Iuzzolino, Valentina Virginia Senerchia, Gianmaria Brescia Morra, Vincenzo Nolano, Maria Costagliola, Ciro Dubbioso, Raffaele |
author_sort | Cennamo, Gilda |
collection | PubMed |
description | Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization by means of spectral-domain (SD-OCT) and optical coherence tomography angiography (OCT-A) in ALS patients. We enrolled 48 ALS patients and 45 healthy controls. ALS patients were divided into three groups: slow progressors (n = 10), intermediate progressors (n = 24) and fast progressors (n = 14), according to the disease progression rate. For SD-OCT, we evaluated the Subfoveal choroidal thickness (SFCT), ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). Regarding the OCT-A, we assessed the vessel density (VD) in superficial and deep capillary plexuses, radial peripapillary capillary plexus, choriocapillary and the foveal avascular zone (FAZ) area. SD-OCT exam did not show any significant differences in GCC and RNFL thickness between patients and controls and among the three ALS groups. The SFCT was statistically greater in patients compared with controls (357.95 ± 55.15 µm vs. 301.3 ± 55.80 µm, p < 0.001); interestingly, the SFCT was thicker in patients with slow and intermediate disease progression than in those with fast disease progression (394.45 ± 53.73 µm vs. 393.09 ± 42.17 µm vs. 267.71 ± 56.24 µm, p < 0.001). OCT-A did not reveal any significant results. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-r) and disease duration did not correlate with any of the OCT parameters, except for SFCT with ALSFRS-r (r = 0.753, p = 0.024). This study demonstrated the possible association between choroidal thickness and disease activity in ALS. OCT could be a useful biomarker in the management of the disease. |
format | Online Article Text |
id | pubmed-9598742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95987422022-10-27 Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis Cennamo, Gilda Montorio, Daniela Ausiello, Francesco Pio Magno, Luigifilippo Iodice, Rosa Mazzucco, Alberto Iuzzolino, Valentina Virginia Senerchia, Gianmaria Brescia Morra, Vincenzo Nolano, Maria Costagliola, Ciro Dubbioso, Raffaele Biomedicines Article Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization by means of spectral-domain (SD-OCT) and optical coherence tomography angiography (OCT-A) in ALS patients. We enrolled 48 ALS patients and 45 healthy controls. ALS patients were divided into three groups: slow progressors (n = 10), intermediate progressors (n = 24) and fast progressors (n = 14), according to the disease progression rate. For SD-OCT, we evaluated the Subfoveal choroidal thickness (SFCT), ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). Regarding the OCT-A, we assessed the vessel density (VD) in superficial and deep capillary plexuses, radial peripapillary capillary plexus, choriocapillary and the foveal avascular zone (FAZ) area. SD-OCT exam did not show any significant differences in GCC and RNFL thickness between patients and controls and among the three ALS groups. The SFCT was statistically greater in patients compared with controls (357.95 ± 55.15 µm vs. 301.3 ± 55.80 µm, p < 0.001); interestingly, the SFCT was thicker in patients with slow and intermediate disease progression than in those with fast disease progression (394.45 ± 53.73 µm vs. 393.09 ± 42.17 µm vs. 267.71 ± 56.24 µm, p < 0.001). OCT-A did not reveal any significant results. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-r) and disease duration did not correlate with any of the OCT parameters, except for SFCT with ALSFRS-r (r = 0.753, p = 0.024). This study demonstrated the possible association between choroidal thickness and disease activity in ALS. OCT could be a useful biomarker in the management of the disease. MDPI 2022-09-25 /pmc/articles/PMC9598742/ /pubmed/36289652 http://dx.doi.org/10.3390/biomedicines10102390 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cennamo, Gilda Montorio, Daniela Ausiello, Francesco Pio Magno, Luigifilippo Iodice, Rosa Mazzucco, Alberto Iuzzolino, Valentina Virginia Senerchia, Gianmaria Brescia Morra, Vincenzo Nolano, Maria Costagliola, Ciro Dubbioso, Raffaele Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis |
title | Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis |
title_full | Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis |
title_fullStr | Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis |
title_short | Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis |
title_sort | correlation between retinal vascularization and disease aggressiveness in amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598742/ https://www.ncbi.nlm.nih.gov/pubmed/36289652 http://dx.doi.org/10.3390/biomedicines10102390 |
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