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Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis

Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization...

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Autores principales: Cennamo, Gilda, Montorio, Daniela, Ausiello, Francesco Pio, Magno, Luigifilippo, Iodice, Rosa, Mazzucco, Alberto, Iuzzolino, Valentina Virginia, Senerchia, Gianmaria, Brescia Morra, Vincenzo, Nolano, Maria, Costagliola, Ciro, Dubbioso, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598742/
https://www.ncbi.nlm.nih.gov/pubmed/36289652
http://dx.doi.org/10.3390/biomedicines10102390
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author Cennamo, Gilda
Montorio, Daniela
Ausiello, Francesco Pio
Magno, Luigifilippo
Iodice, Rosa
Mazzucco, Alberto
Iuzzolino, Valentina Virginia
Senerchia, Gianmaria
Brescia Morra, Vincenzo
Nolano, Maria
Costagliola, Ciro
Dubbioso, Raffaele
author_facet Cennamo, Gilda
Montorio, Daniela
Ausiello, Francesco Pio
Magno, Luigifilippo
Iodice, Rosa
Mazzucco, Alberto
Iuzzolino, Valentina Virginia
Senerchia, Gianmaria
Brescia Morra, Vincenzo
Nolano, Maria
Costagliola, Ciro
Dubbioso, Raffaele
author_sort Cennamo, Gilda
collection PubMed
description Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization by means of spectral-domain (SD-OCT) and optical coherence tomography angiography (OCT-A) in ALS patients. We enrolled 48 ALS patients and 45 healthy controls. ALS patients were divided into three groups: slow progressors (n = 10), intermediate progressors (n = 24) and fast progressors (n = 14), according to the disease progression rate. For SD-OCT, we evaluated the Subfoveal choroidal thickness (SFCT), ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). Regarding the OCT-A, we assessed the vessel density (VD) in superficial and deep capillary plexuses, radial peripapillary capillary plexus, choriocapillary and the foveal avascular zone (FAZ) area. SD-OCT exam did not show any significant differences in GCC and RNFL thickness between patients and controls and among the three ALS groups. The SFCT was statistically greater in patients compared with controls (357.95 ± 55.15 µm vs. 301.3 ± 55.80 µm, p < 0.001); interestingly, the SFCT was thicker in patients with slow and intermediate disease progression than in those with fast disease progression (394.45 ± 53.73 µm vs. 393.09 ± 42.17 µm vs. 267.71 ± 56.24 µm, p < 0.001). OCT-A did not reveal any significant results. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-r) and disease duration did not correlate with any of the OCT parameters, except for SFCT with ALSFRS-r (r = 0.753, p = 0.024). This study demonstrated the possible association between choroidal thickness and disease activity in ALS. OCT could be a useful biomarker in the management of the disease.
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spelling pubmed-95987422022-10-27 Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis Cennamo, Gilda Montorio, Daniela Ausiello, Francesco Pio Magno, Luigifilippo Iodice, Rosa Mazzucco, Alberto Iuzzolino, Valentina Virginia Senerchia, Gianmaria Brescia Morra, Vincenzo Nolano, Maria Costagliola, Ciro Dubbioso, Raffaele Biomedicines Article Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization by means of spectral-domain (SD-OCT) and optical coherence tomography angiography (OCT-A) in ALS patients. We enrolled 48 ALS patients and 45 healthy controls. ALS patients were divided into three groups: slow progressors (n = 10), intermediate progressors (n = 24) and fast progressors (n = 14), according to the disease progression rate. For SD-OCT, we evaluated the Subfoveal choroidal thickness (SFCT), ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). Regarding the OCT-A, we assessed the vessel density (VD) in superficial and deep capillary plexuses, radial peripapillary capillary plexus, choriocapillary and the foveal avascular zone (FAZ) area. SD-OCT exam did not show any significant differences in GCC and RNFL thickness between patients and controls and among the three ALS groups. The SFCT was statistically greater in patients compared with controls (357.95 ± 55.15 µm vs. 301.3 ± 55.80 µm, p < 0.001); interestingly, the SFCT was thicker in patients with slow and intermediate disease progression than in those with fast disease progression (394.45 ± 53.73 µm vs. 393.09 ± 42.17 µm vs. 267.71 ± 56.24 µm, p < 0.001). OCT-A did not reveal any significant results. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-r) and disease duration did not correlate with any of the OCT parameters, except for SFCT with ALSFRS-r (r = 0.753, p = 0.024). This study demonstrated the possible association between choroidal thickness and disease activity in ALS. OCT could be a useful biomarker in the management of the disease. MDPI 2022-09-25 /pmc/articles/PMC9598742/ /pubmed/36289652 http://dx.doi.org/10.3390/biomedicines10102390 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cennamo, Gilda
Montorio, Daniela
Ausiello, Francesco Pio
Magno, Luigifilippo
Iodice, Rosa
Mazzucco, Alberto
Iuzzolino, Valentina Virginia
Senerchia, Gianmaria
Brescia Morra, Vincenzo
Nolano, Maria
Costagliola, Ciro
Dubbioso, Raffaele
Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
title Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
title_full Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
title_fullStr Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
title_full_unstemmed Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
title_short Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
title_sort correlation between retinal vascularization and disease aggressiveness in amyotrophic lateral sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598742/
https://www.ncbi.nlm.nih.gov/pubmed/36289652
http://dx.doi.org/10.3390/biomedicines10102390
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