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Telomeres and Telomerase in the Control of Stem Cells
Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598777/ https://www.ncbi.nlm.nih.gov/pubmed/36289597 http://dx.doi.org/10.3390/biomedicines10102335 |
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author | Lupatov, Alexey Yu. Yarygin, Konstantin N. |
author_facet | Lupatov, Alexey Yu. Yarygin, Konstantin N. |
author_sort | Lupatov, Alexey Yu. |
collection | PubMed |
description | Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerative potential of high-turnover organs, causing or contributing to the onset of age-related diseases. In this review, stem cells are examined in the context of the current telomere-centric theory of cell aging, which assumes that telomere shortening depends not just on the number of cell doublings (mitotic clock) but also on the influence of various internal and external factors. The influence of the telomerase and telomere length on the functional activity of different stem cell types, as well as on their aging and prospects of use in cell therapy applications, is discussed. |
format | Online Article Text |
id | pubmed-9598777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95987772022-10-27 Telomeres and Telomerase in the Control of Stem Cells Lupatov, Alexey Yu. Yarygin, Konstantin N. Biomedicines Review Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerative potential of high-turnover organs, causing or contributing to the onset of age-related diseases. In this review, stem cells are examined in the context of the current telomere-centric theory of cell aging, which assumes that telomere shortening depends not just on the number of cell doublings (mitotic clock) but also on the influence of various internal and external factors. The influence of the telomerase and telomere length on the functional activity of different stem cell types, as well as on their aging and prospects of use in cell therapy applications, is discussed. MDPI 2022-09-20 /pmc/articles/PMC9598777/ /pubmed/36289597 http://dx.doi.org/10.3390/biomedicines10102335 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lupatov, Alexey Yu. Yarygin, Konstantin N. Telomeres and Telomerase in the Control of Stem Cells |
title | Telomeres and Telomerase in the Control of Stem Cells |
title_full | Telomeres and Telomerase in the Control of Stem Cells |
title_fullStr | Telomeres and Telomerase in the Control of Stem Cells |
title_full_unstemmed | Telomeres and Telomerase in the Control of Stem Cells |
title_short | Telomeres and Telomerase in the Control of Stem Cells |
title_sort | telomeres and telomerase in the control of stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598777/ https://www.ncbi.nlm.nih.gov/pubmed/36289597 http://dx.doi.org/10.3390/biomedicines10102335 |
work_keys_str_mv | AT lupatovalexeyyu telomeresandtelomeraseinthecontrolofstemcells AT yaryginkonstantinn telomeresandtelomeraseinthecontrolofstemcells |