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Telomeres and Telomerase in the Control of Stem Cells

Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerati...

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Autores principales: Lupatov, Alexey Yu., Yarygin, Konstantin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598777/
https://www.ncbi.nlm.nih.gov/pubmed/36289597
http://dx.doi.org/10.3390/biomedicines10102335
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author Lupatov, Alexey Yu.
Yarygin, Konstantin N.
author_facet Lupatov, Alexey Yu.
Yarygin, Konstantin N.
author_sort Lupatov, Alexey Yu.
collection PubMed
description Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerative potential of high-turnover organs, causing or contributing to the onset of age-related diseases. In this review, stem cells are examined in the context of the current telomere-centric theory of cell aging, which assumes that telomere shortening depends not just on the number of cell doublings (mitotic clock) but also on the influence of various internal and external factors. The influence of the telomerase and telomere length on the functional activity of different stem cell types, as well as on their aging and prospects of use in cell therapy applications, is discussed.
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spelling pubmed-95987772022-10-27 Telomeres and Telomerase in the Control of Stem Cells Lupatov, Alexey Yu. Yarygin, Konstantin N. Biomedicines Review Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerative potential of high-turnover organs, causing or contributing to the onset of age-related diseases. In this review, stem cells are examined in the context of the current telomere-centric theory of cell aging, which assumes that telomere shortening depends not just on the number of cell doublings (mitotic clock) but also on the influence of various internal and external factors. The influence of the telomerase and telomere length on the functional activity of different stem cell types, as well as on their aging and prospects of use in cell therapy applications, is discussed. MDPI 2022-09-20 /pmc/articles/PMC9598777/ /pubmed/36289597 http://dx.doi.org/10.3390/biomedicines10102335 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lupatov, Alexey Yu.
Yarygin, Konstantin N.
Telomeres and Telomerase in the Control of Stem Cells
title Telomeres and Telomerase in the Control of Stem Cells
title_full Telomeres and Telomerase in the Control of Stem Cells
title_fullStr Telomeres and Telomerase in the Control of Stem Cells
title_full_unstemmed Telomeres and Telomerase in the Control of Stem Cells
title_short Telomeres and Telomerase in the Control of Stem Cells
title_sort telomeres and telomerase in the control of stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598777/
https://www.ncbi.nlm.nih.gov/pubmed/36289597
http://dx.doi.org/10.3390/biomedicines10102335
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