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Antimicrobial Activity of Lactones

The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimic...

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Autores principales: Mazur, Marcelina, Masłowiec, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598898/
https://www.ncbi.nlm.nih.gov/pubmed/36289985
http://dx.doi.org/10.3390/antibiotics11101327
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author Mazur, Marcelina
Masłowiec, Dorota
author_facet Mazur, Marcelina
Masłowiec, Dorota
author_sort Mazur, Marcelina
collection PubMed
description The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein.
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spelling pubmed-95988982022-10-27 Antimicrobial Activity of Lactones Mazur, Marcelina Masłowiec, Dorota Antibiotics (Basel) Review The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein. MDPI 2022-09-29 /pmc/articles/PMC9598898/ /pubmed/36289985 http://dx.doi.org/10.3390/antibiotics11101327 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mazur, Marcelina
Masłowiec, Dorota
Antimicrobial Activity of Lactones
title Antimicrobial Activity of Lactones
title_full Antimicrobial Activity of Lactones
title_fullStr Antimicrobial Activity of Lactones
title_full_unstemmed Antimicrobial Activity of Lactones
title_short Antimicrobial Activity of Lactones
title_sort antimicrobial activity of lactones
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598898/
https://www.ncbi.nlm.nih.gov/pubmed/36289985
http://dx.doi.org/10.3390/antibiotics11101327
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