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Antimicrobial Activity of Lactones
The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598898/ https://www.ncbi.nlm.nih.gov/pubmed/36289985 http://dx.doi.org/10.3390/antibiotics11101327 |
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author | Mazur, Marcelina Masłowiec, Dorota |
author_facet | Mazur, Marcelina Masłowiec, Dorota |
author_sort | Mazur, Marcelina |
collection | PubMed |
description | The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein. |
format | Online Article Text |
id | pubmed-9598898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95988982022-10-27 Antimicrobial Activity of Lactones Mazur, Marcelina Masłowiec, Dorota Antibiotics (Basel) Review The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein. MDPI 2022-09-29 /pmc/articles/PMC9598898/ /pubmed/36289985 http://dx.doi.org/10.3390/antibiotics11101327 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mazur, Marcelina Masłowiec, Dorota Antimicrobial Activity of Lactones |
title | Antimicrobial Activity of Lactones |
title_full | Antimicrobial Activity of Lactones |
title_fullStr | Antimicrobial Activity of Lactones |
title_full_unstemmed | Antimicrobial Activity of Lactones |
title_short | Antimicrobial Activity of Lactones |
title_sort | antimicrobial activity of lactones |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598898/ https://www.ncbi.nlm.nih.gov/pubmed/36289985 http://dx.doi.org/10.3390/antibiotics11101327 |
work_keys_str_mv | AT mazurmarcelina antimicrobialactivityoflactones AT masłowiecdorota antimicrobialactivityoflactones |