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Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation

The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare th...

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Autores principales: Tay, Benjamin Wei Rong, Huang, Daniel Q., Mark, Muthiah, Thong, Neo Wee, Guan Huei, Lee, Gee, Lim Seng, Cheng, Low How, Mei, Lee Yin, Thurairajah, Prem, Chen, Lim Jia, Ng, Cheng Han, Lim, Wen Hui, Tan, Darren Jun Hao, Maureen, Da Costa, Alfred, Kow Wei Chieh, Ganpathi, Iyer Shridar, Seng, Tan Poh, Young, Dan Yock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598932/
https://www.ncbi.nlm.nih.gov/pubmed/36289623
http://dx.doi.org/10.3390/biomedicines10102361
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author Tay, Benjamin Wei Rong
Huang, Daniel Q.
Mark, Muthiah
Thong, Neo Wee
Guan Huei, Lee
Gee, Lim Seng
Cheng, Low How
Mei, Lee Yin
Thurairajah, Prem
Chen, Lim Jia
Ng, Cheng Han
Lim, Wen Hui
Tan, Darren Jun Hao
Maureen, Da Costa
Alfred, Kow Wei Chieh
Ganpathi, Iyer Shridar
Seng, Tan Poh
Young, Dan Yock
author_facet Tay, Benjamin Wei Rong
Huang, Daniel Q.
Mark, Muthiah
Thong, Neo Wee
Guan Huei, Lee
Gee, Lim Seng
Cheng, Low How
Mei, Lee Yin
Thurairajah, Prem
Chen, Lim Jia
Ng, Cheng Han
Lim, Wen Hui
Tan, Darren Jun Hao
Maureen, Da Costa
Alfred, Kow Wei Chieh
Ganpathi, Iyer Shridar
Seng, Tan Poh
Young, Dan Yock
author_sort Tay, Benjamin Wei Rong
collection PubMed
description The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare the clinical outcomes for TACE and RFA in early HCC. All consecutive patients from 2010 to 2014 that were treated with locoregional therapy at our institution were enrolled. The decision for TACE or RFA was based on tumor location, stage and technical accessibility for ablation. A subgroup analysis was performed for patients with tumors less than 3 cm. A total of 168 patients underwent TACE while 56 patients underwent RFA. Patients treated with TACE and RFA had 1- and 5-year survival rates of 84.7% and 39.8% versus 91.5% and 51.5%, respectively (p = 0.28). In tumors less than 3 cm, there was no significant difference in overall survival (p = 0.69), time to progression (p = 0.55), or number of treatment sessions required (p = 0.12). Radiofrequency ablation had a significantly higher chance of a complete response (p = 0.004). In conclusion, TACE may be selectively considered for early-stage hepatocellular carcinoma in patients unsuitable for other modalities.
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spelling pubmed-95989322022-10-27 Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation Tay, Benjamin Wei Rong Huang, Daniel Q. Mark, Muthiah Thong, Neo Wee Guan Huei, Lee Gee, Lim Seng Cheng, Low How Mei, Lee Yin Thurairajah, Prem Chen, Lim Jia Ng, Cheng Han Lim, Wen Hui Tan, Darren Jun Hao Maureen, Da Costa Alfred, Kow Wei Chieh Ganpathi, Iyer Shridar Seng, Tan Poh Young, Dan Yock Biomedicines Article The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare the clinical outcomes for TACE and RFA in early HCC. All consecutive patients from 2010 to 2014 that were treated with locoregional therapy at our institution were enrolled. The decision for TACE or RFA was based on tumor location, stage and technical accessibility for ablation. A subgroup analysis was performed for patients with tumors less than 3 cm. A total of 168 patients underwent TACE while 56 patients underwent RFA. Patients treated with TACE and RFA had 1- and 5-year survival rates of 84.7% and 39.8% versus 91.5% and 51.5%, respectively (p = 0.28). In tumors less than 3 cm, there was no significant difference in overall survival (p = 0.69), time to progression (p = 0.55), or number of treatment sessions required (p = 0.12). Radiofrequency ablation had a significantly higher chance of a complete response (p = 0.004). In conclusion, TACE may be selectively considered for early-stage hepatocellular carcinoma in patients unsuitable for other modalities. MDPI 2022-09-22 /pmc/articles/PMC9598932/ /pubmed/36289623 http://dx.doi.org/10.3390/biomedicines10102361 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tay, Benjamin Wei Rong
Huang, Daniel Q.
Mark, Muthiah
Thong, Neo Wee
Guan Huei, Lee
Gee, Lim Seng
Cheng, Low How
Mei, Lee Yin
Thurairajah, Prem
Chen, Lim Jia
Ng, Cheng Han
Lim, Wen Hui
Tan, Darren Jun Hao
Maureen, Da Costa
Alfred, Kow Wei Chieh
Ganpathi, Iyer Shridar
Seng, Tan Poh
Young, Dan Yock
Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
title Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
title_full Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
title_fullStr Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
title_full_unstemmed Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
title_short Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
title_sort comparable outcomes in early hepatocellular carcinomas treated with trans-arterial chemoembolization and radiofrequency ablation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598932/
https://www.ncbi.nlm.nih.gov/pubmed/36289623
http://dx.doi.org/10.3390/biomedicines10102361
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