Cargando…
Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation
The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare th...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598932/ https://www.ncbi.nlm.nih.gov/pubmed/36289623 http://dx.doi.org/10.3390/biomedicines10102361 |
_version_ | 1784816470610411520 |
---|---|
author | Tay, Benjamin Wei Rong Huang, Daniel Q. Mark, Muthiah Thong, Neo Wee Guan Huei, Lee Gee, Lim Seng Cheng, Low How Mei, Lee Yin Thurairajah, Prem Chen, Lim Jia Ng, Cheng Han Lim, Wen Hui Tan, Darren Jun Hao Maureen, Da Costa Alfred, Kow Wei Chieh Ganpathi, Iyer Shridar Seng, Tan Poh Young, Dan Yock |
author_facet | Tay, Benjamin Wei Rong Huang, Daniel Q. Mark, Muthiah Thong, Neo Wee Guan Huei, Lee Gee, Lim Seng Cheng, Low How Mei, Lee Yin Thurairajah, Prem Chen, Lim Jia Ng, Cheng Han Lim, Wen Hui Tan, Darren Jun Hao Maureen, Da Costa Alfred, Kow Wei Chieh Ganpathi, Iyer Shridar Seng, Tan Poh Young, Dan Yock |
author_sort | Tay, Benjamin Wei Rong |
collection | PubMed |
description | The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare the clinical outcomes for TACE and RFA in early HCC. All consecutive patients from 2010 to 2014 that were treated with locoregional therapy at our institution were enrolled. The decision for TACE or RFA was based on tumor location, stage and technical accessibility for ablation. A subgroup analysis was performed for patients with tumors less than 3 cm. A total of 168 patients underwent TACE while 56 patients underwent RFA. Patients treated with TACE and RFA had 1- and 5-year survival rates of 84.7% and 39.8% versus 91.5% and 51.5%, respectively (p = 0.28). In tumors less than 3 cm, there was no significant difference in overall survival (p = 0.69), time to progression (p = 0.55), or number of treatment sessions required (p = 0.12). Radiofrequency ablation had a significantly higher chance of a complete response (p = 0.004). In conclusion, TACE may be selectively considered for early-stage hepatocellular carcinoma in patients unsuitable for other modalities. |
format | Online Article Text |
id | pubmed-9598932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95989322022-10-27 Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation Tay, Benjamin Wei Rong Huang, Daniel Q. Mark, Muthiah Thong, Neo Wee Guan Huei, Lee Gee, Lim Seng Cheng, Low How Mei, Lee Yin Thurairajah, Prem Chen, Lim Jia Ng, Cheng Han Lim, Wen Hui Tan, Darren Jun Hao Maureen, Da Costa Alfred, Kow Wei Chieh Ganpathi, Iyer Shridar Seng, Tan Poh Young, Dan Yock Biomedicines Article The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare the clinical outcomes for TACE and RFA in early HCC. All consecutive patients from 2010 to 2014 that were treated with locoregional therapy at our institution were enrolled. The decision for TACE or RFA was based on tumor location, stage and technical accessibility for ablation. A subgroup analysis was performed for patients with tumors less than 3 cm. A total of 168 patients underwent TACE while 56 patients underwent RFA. Patients treated with TACE and RFA had 1- and 5-year survival rates of 84.7% and 39.8% versus 91.5% and 51.5%, respectively (p = 0.28). In tumors less than 3 cm, there was no significant difference in overall survival (p = 0.69), time to progression (p = 0.55), or number of treatment sessions required (p = 0.12). Radiofrequency ablation had a significantly higher chance of a complete response (p = 0.004). In conclusion, TACE may be selectively considered for early-stage hepatocellular carcinoma in patients unsuitable for other modalities. MDPI 2022-09-22 /pmc/articles/PMC9598932/ /pubmed/36289623 http://dx.doi.org/10.3390/biomedicines10102361 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tay, Benjamin Wei Rong Huang, Daniel Q. Mark, Muthiah Thong, Neo Wee Guan Huei, Lee Gee, Lim Seng Cheng, Low How Mei, Lee Yin Thurairajah, Prem Chen, Lim Jia Ng, Cheng Han Lim, Wen Hui Tan, Darren Jun Hao Maureen, Da Costa Alfred, Kow Wei Chieh Ganpathi, Iyer Shridar Seng, Tan Poh Young, Dan Yock Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation |
title | Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation |
title_full | Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation |
title_fullStr | Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation |
title_full_unstemmed | Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation |
title_short | Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation |
title_sort | comparable outcomes in early hepatocellular carcinomas treated with trans-arterial chemoembolization and radiofrequency ablation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598932/ https://www.ncbi.nlm.nih.gov/pubmed/36289623 http://dx.doi.org/10.3390/biomedicines10102361 |
work_keys_str_mv | AT taybenjaminweirong comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT huangdanielq comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT markmuthiah comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT thongneowee comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT guanhueilee comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT geelimseng comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT chenglowhow comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT meileeyin comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT thurairajahprem comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT chenlimjia comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT ngchenghan comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT limwenhui comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT tandarrenjunhao comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT maureendacosta comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT alfredkowweichieh comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT ganpathiiyershridar comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT sengtanpoh comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation AT youngdanyock comparableoutcomesinearlyhepatocellularcarcinomastreatedwithtransarterialchemoembolizationandradiofrequencyablation |