Folic Acid Improves Parkin-Null Drosophila Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and Glutathione Redox Equilibrium

Loss-of-function parkin mutations cause oxidative stress and degeneration of dopaminergic neurons in the substantia nigra. Several consequences of parkin mutations have been described; to what degree they contribute to selective neurodegeneration remains unclear. Specific factors initiating excessiv...

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Detalles Bibliográficos
Autores principales: Houlihan, Katherine L., Keoseyan, Petros P., Juba, Amber N., Margaryan, Tigran, Voss, Max E., Babaoghli, Alexander M., Norris, Justin M., Adrian, Greg J., Tovmasyan, Artak, Buhlman, Lori M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598960/
https://www.ncbi.nlm.nih.gov/pubmed/36290790
http://dx.doi.org/10.3390/antiox11102068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598960/
https://www.ncbi.nlm.nih.gov/pubmed/36290790
http://dx.doi.org/10.3390/antiox11102068

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