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Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin

SIMPLE SUMMARY: Intrauterine growth restriction is an increasingly concerning issue for human pregnancies because of its perinatal and longer-term consequences on offspring health. We have explored, in a swine model, differences in the adult phenotype of offspring with low birth weight induced by ma...

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Autores principales: Heras-Molina, Ana, Yeste, Natalia, Pesantez-Pacheco, José Luis, Astiz, Susana, Vazquez-Gomez, Marta, Bettiga, Arianna, Trevisani, Francesco, Garcia-Contreras, Consolacion, Luis-Lima, Sergio, Bassols, Anna, Porrini, Esteban, Gonzalez-Bulnes, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598994/
https://www.ncbi.nlm.nih.gov/pubmed/36290436
http://dx.doi.org/10.3390/biology11101533
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author Heras-Molina, Ana
Yeste, Natalia
Pesantez-Pacheco, José Luis
Astiz, Susana
Vazquez-Gomez, Marta
Bettiga, Arianna
Trevisani, Francesco
Garcia-Contreras, Consolacion
Luis-Lima, Sergio
Bassols, Anna
Porrini, Esteban
Gonzalez-Bulnes, Antonio
author_facet Heras-Molina, Ana
Yeste, Natalia
Pesantez-Pacheco, José Luis
Astiz, Susana
Vazquez-Gomez, Marta
Bettiga, Arianna
Trevisani, Francesco
Garcia-Contreras, Consolacion
Luis-Lima, Sergio
Bassols, Anna
Porrini, Esteban
Gonzalez-Bulnes, Antonio
author_sort Heras-Molina, Ana
collection PubMed
description SIMPLE SUMMARY: Intrauterine growth restriction is an increasingly concerning issue for human pregnancies because of its perinatal and longer-term consequences on offspring health. We have explored, in a swine model, differences in the adult phenotype of offspring with low birth weight induced by maternal malnutrition or placental insufficiency. ABSTRACT: Intrauterine growth restriction (IUGR) and later obesity and metabolic disorders have classically been associated with maternal malnutrition, but most cases of IUGR are related to placental insufficiency. The current study, using a swine model for IUGR and obesity, aimed to determine the interaction of birth weight (categorized as low birth weight [LBW] or normal birth-weight [NBW]) and postnatal diet (categorized as maintenance diet [MD] or fattening diet [FD]) on body weight, adiposity and metabolic traits. FD induced higher body weight and adiposity (both p < 0.0001), with higher fructosamine levels (p < 0.005) and a trend toward higher HOMA-β index (p = 0.05). NBW pigs remained heavier than LBW pigs during the early juvenile period (p < 0.005), but there were no differences at later stages. There were no differences in metabolic traits during juvenile development, but there were differences in adulthood, when LBW pigs showed higher glucose and lower insulin levels than NBW pigs (both p < 0.05). These results suggest that (a) FD allows LBW offspring to achieve similar obesity in adulthood as NBW offspring, and (b) glucose metabolism is more compromised in obese LBW than obese NBW pigs. The comparison of our data with previous studies highlights significant differences between offspring with LBW induced by maternal malnutrition or placental insufficiency, which should be considered when studying the condition.
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spelling pubmed-95989942022-10-27 Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin Heras-Molina, Ana Yeste, Natalia Pesantez-Pacheco, José Luis Astiz, Susana Vazquez-Gomez, Marta Bettiga, Arianna Trevisani, Francesco Garcia-Contreras, Consolacion Luis-Lima, Sergio Bassols, Anna Porrini, Esteban Gonzalez-Bulnes, Antonio Biology (Basel) Article SIMPLE SUMMARY: Intrauterine growth restriction is an increasingly concerning issue for human pregnancies because of its perinatal and longer-term consequences on offspring health. We have explored, in a swine model, differences in the adult phenotype of offspring with low birth weight induced by maternal malnutrition or placental insufficiency. ABSTRACT: Intrauterine growth restriction (IUGR) and later obesity and metabolic disorders have classically been associated with maternal malnutrition, but most cases of IUGR are related to placental insufficiency. The current study, using a swine model for IUGR and obesity, aimed to determine the interaction of birth weight (categorized as low birth weight [LBW] or normal birth-weight [NBW]) and postnatal diet (categorized as maintenance diet [MD] or fattening diet [FD]) on body weight, adiposity and metabolic traits. FD induced higher body weight and adiposity (both p < 0.0001), with higher fructosamine levels (p < 0.005) and a trend toward higher HOMA-β index (p = 0.05). NBW pigs remained heavier than LBW pigs during the early juvenile period (p < 0.005), but there were no differences at later stages. There were no differences in metabolic traits during juvenile development, but there were differences in adulthood, when LBW pigs showed higher glucose and lower insulin levels than NBW pigs (both p < 0.05). These results suggest that (a) FD allows LBW offspring to achieve similar obesity in adulthood as NBW offspring, and (b) glucose metabolism is more compromised in obese LBW than obese NBW pigs. The comparison of our data with previous studies highlights significant differences between offspring with LBW induced by maternal malnutrition or placental insufficiency, which should be considered when studying the condition. MDPI 2022-10-19 /pmc/articles/PMC9598994/ /pubmed/36290436 http://dx.doi.org/10.3390/biology11101533 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heras-Molina, Ana
Yeste, Natalia
Pesantez-Pacheco, José Luis
Astiz, Susana
Vazquez-Gomez, Marta
Bettiga, Arianna
Trevisani, Francesco
Garcia-Contreras, Consolacion
Luis-Lima, Sergio
Bassols, Anna
Porrini, Esteban
Gonzalez-Bulnes, Antonio
Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
title Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
title_full Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
title_fullStr Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
title_full_unstemmed Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
title_short Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin
title_sort obesity and metabolic traits after high-fat diet in iberian pigs with low birth weight of placental origin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598994/
https://www.ncbi.nlm.nih.gov/pubmed/36290436
http://dx.doi.org/10.3390/biology11101533
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