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Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients

The adequate regulation of postoperative serum glucose level (SGL) is widely accepted; however, the effects for non-diabetic patients who underwent major pancreatic surgery have not yet been established. We discerned the relevance of the immediately postoperative SGL to short-term postoperative outc...

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Autores principales: Lee, Okjoo, Lim, Chang-Sup, Yoon, So Jeong, Jung, Ji Hye, Shin, Sang Hyun, Heo, Jin Seok, Shin, Yong Chan, Jung, Woohyun, Han, In Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599123/
https://www.ncbi.nlm.nih.gov/pubmed/36289689
http://dx.doi.org/10.3390/biomedicines10102427
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author Lee, Okjoo
Lim, Chang-Sup
Yoon, So Jeong
Jung, Ji Hye
Shin, Sang Hyun
Heo, Jin Seok
Shin, Yong Chan
Jung, Woohyun
Han, In Woong
author_facet Lee, Okjoo
Lim, Chang-Sup
Yoon, So Jeong
Jung, Ji Hye
Shin, Sang Hyun
Heo, Jin Seok
Shin, Yong Chan
Jung, Woohyun
Han, In Woong
author_sort Lee, Okjoo
collection PubMed
description The adequate regulation of postoperative serum glucose level (SGL) is widely accepted; however, the effects for non-diabetic patients who underwent major pancreatic surgery have not yet been established. We discerned the relevance of the immediately postoperative SGL to short-term postoperative outcomes from major pancreatic surgery in non-diabetic patients. Between January 2007 and December 2016, 2259 non-diabetic patients underwent major pancreatic surgery at four tertiary medical centers in Republic of Korea. Based on a SGL of 200 mg/dL, patients were classified into two groups by averaging the results of four SGL tests taken on the first day after surgery, and their short-term postoperative outcomes were analyzed. A 1:1 propensity score matching method was conducted to establish the high SGL group (n = 568) and the normal SGL group (n = 568). The high SGL group experienced a significantly higher rate of level C complications in the Clavien-Dindo classification (CDc) than the normal SGL group (24.1% vs. 16.5%, p = 0.002). Additionally, an SGL of more than 200 mg/dL was associated with a significantly high risk of complications above level C CDc after adjusting for other risk factors (hazard ratio = 1.324, 95% confidence interval = 1.048–1.672, p = 0.019). The regulation of SGL of less than 200 mg/dL in non-diabetic patients early after major pancreatic surgery could be helpful for reducing postoperative complications.
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spelling pubmed-95991232022-10-27 Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients Lee, Okjoo Lim, Chang-Sup Yoon, So Jeong Jung, Ji Hye Shin, Sang Hyun Heo, Jin Seok Shin, Yong Chan Jung, Woohyun Han, In Woong Biomedicines Article The adequate regulation of postoperative serum glucose level (SGL) is widely accepted; however, the effects for non-diabetic patients who underwent major pancreatic surgery have not yet been established. We discerned the relevance of the immediately postoperative SGL to short-term postoperative outcomes from major pancreatic surgery in non-diabetic patients. Between January 2007 and December 2016, 2259 non-diabetic patients underwent major pancreatic surgery at four tertiary medical centers in Republic of Korea. Based on a SGL of 200 mg/dL, patients were classified into two groups by averaging the results of four SGL tests taken on the first day after surgery, and their short-term postoperative outcomes were analyzed. A 1:1 propensity score matching method was conducted to establish the high SGL group (n = 568) and the normal SGL group (n = 568). The high SGL group experienced a significantly higher rate of level C complications in the Clavien-Dindo classification (CDc) than the normal SGL group (24.1% vs. 16.5%, p = 0.002). Additionally, an SGL of more than 200 mg/dL was associated with a significantly high risk of complications above level C CDc after adjusting for other risk factors (hazard ratio = 1.324, 95% confidence interval = 1.048–1.672, p = 0.019). The regulation of SGL of less than 200 mg/dL in non-diabetic patients early after major pancreatic surgery could be helpful for reducing postoperative complications. MDPI 2022-09-28 /pmc/articles/PMC9599123/ /pubmed/36289689 http://dx.doi.org/10.3390/biomedicines10102427 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Okjoo
Lim, Chang-Sup
Yoon, So Jeong
Jung, Ji Hye
Shin, Sang Hyun
Heo, Jin Seok
Shin, Yong Chan
Jung, Woohyun
Han, In Woong
Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients
title Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients
title_full Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients
title_fullStr Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients
title_full_unstemmed Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients
title_short Comparison of Short-Term Surgical Outcomes According to Immediately Postoperative Serum Glucose Level in Non-Diabetic Pancreatic Resection Patients
title_sort comparison of short-term surgical outcomes according to immediately postoperative serum glucose level in non-diabetic pancreatic resection patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599123/
https://www.ncbi.nlm.nih.gov/pubmed/36289689
http://dx.doi.org/10.3390/biomedicines10102427
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