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The Role of Autophagy in Osteoarthritic Cartilage
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules an...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599131/ https://www.ncbi.nlm.nih.gov/pubmed/36291565 http://dx.doi.org/10.3390/biom12101357 |
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author | Kao, Wei-Chun Chen, Jian-Chih Liu, Ping-Cheng Lu, Cheng-Chang Lin, Sung-Yen Chuang, Shu-Chun Wu, Shun-Cheng Chang, Ling-hua Lee, Mon-Juan Yang, Chung-Da Lee, Tien-Ching Wang, Ying-Chun Li, Jhong-You Wei, Chun-Wang Chen, Chung-Hwan |
author_facet | Kao, Wei-Chun Chen, Jian-Chih Liu, Ping-Cheng Lu, Cheng-Chang Lin, Sung-Yen Chuang, Shu-Chun Wu, Shun-Cheng Chang, Ling-hua Lee, Mon-Juan Yang, Chung-Da Lee, Tien-Ching Wang, Ying-Chun Li, Jhong-You Wei, Chun-Wang Chen, Chung-Hwan |
author_sort | Kao, Wei-Chun |
collection | PubMed |
description | Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. |
format | Online Article Text |
id | pubmed-9599131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95991312022-10-27 The Role of Autophagy in Osteoarthritic Cartilage Kao, Wei-Chun Chen, Jian-Chih Liu, Ping-Cheng Lu, Cheng-Chang Lin, Sung-Yen Chuang, Shu-Chun Wu, Shun-Cheng Chang, Ling-hua Lee, Mon-Juan Yang, Chung-Da Lee, Tien-Ching Wang, Ying-Chun Li, Jhong-You Wei, Chun-Wang Chen, Chung-Hwan Biomolecules Review Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. MDPI 2022-09-23 /pmc/articles/PMC9599131/ /pubmed/36291565 http://dx.doi.org/10.3390/biom12101357 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kao, Wei-Chun Chen, Jian-Chih Liu, Ping-Cheng Lu, Cheng-Chang Lin, Sung-Yen Chuang, Shu-Chun Wu, Shun-Cheng Chang, Ling-hua Lee, Mon-Juan Yang, Chung-Da Lee, Tien-Ching Wang, Ying-Chun Li, Jhong-You Wei, Chun-Wang Chen, Chung-Hwan The Role of Autophagy in Osteoarthritic Cartilage |
title | The Role of Autophagy in Osteoarthritic Cartilage |
title_full | The Role of Autophagy in Osteoarthritic Cartilage |
title_fullStr | The Role of Autophagy in Osteoarthritic Cartilage |
title_full_unstemmed | The Role of Autophagy in Osteoarthritic Cartilage |
title_short | The Role of Autophagy in Osteoarthritic Cartilage |
title_sort | role of autophagy in osteoarthritic cartilage |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599131/ https://www.ncbi.nlm.nih.gov/pubmed/36291565 http://dx.doi.org/10.3390/biom12101357 |
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