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Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series

Behavioural Activation (BA) is associated with a substantial evidence base for treatment of acute unipolar depression, and has promise as an easily disseminable psychological intervention for bipolar depression. Using a randomised multiple baseline case series design we examined the feasibility and...

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Autores principales: Wright, Kim, Mostazir, Mohammod, Bailey, Ella, Dunn, Barnaby D., O’Mahen, Heather, Sibsey, Michaela, Thomas, Zoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599144/
https://www.ncbi.nlm.nih.gov/pubmed/36291340
http://dx.doi.org/10.3390/brainsci12101407
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author Wright, Kim
Mostazir, Mohammod
Bailey, Ella
Dunn, Barnaby D.
O’Mahen, Heather
Sibsey, Michaela
Thomas, Zoe
author_facet Wright, Kim
Mostazir, Mohammod
Bailey, Ella
Dunn, Barnaby D.
O’Mahen, Heather
Sibsey, Michaela
Thomas, Zoe
author_sort Wright, Kim
collection PubMed
description Behavioural Activation (BA) is associated with a substantial evidence base for treatment of acute unipolar depression, and has promise as an easily disseminable psychological intervention for bipolar depression. Using a randomised multiple baseline case series design we examined the feasibility and acceptability of an adapted version of BA in a U.K. outpatient sample of 12 adults with acute bipolar depression. Participants were allocated at random to a 3–8 week wait period before being offered up to 20 sessions of BA. They completed outcome measures at intake, pre- and post-treatment and weekly symptom measures across the study period. Retention in therapy was high (11/12 participants completed the target minimum number of sessions), and all participants returning acceptability measures reported high levels of satisfaction with the intervention. No therapy-related serious adverse events were reported, nor were there exacerbations in manic symptoms that were judged to be a result of the intervention. The pattern of change on outcome measures is consistent with the potential for clinical benefit; six of the nine participants with a stable baseline showed clinically significant improvement on the primary outcome measure. The findings suggest adapted BA for bipolar depression is a feasible and acceptable approach that merits further investigation.
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spelling pubmed-95991442022-10-27 Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series Wright, Kim Mostazir, Mohammod Bailey, Ella Dunn, Barnaby D. O’Mahen, Heather Sibsey, Michaela Thomas, Zoe Brain Sci Article Behavioural Activation (BA) is associated with a substantial evidence base for treatment of acute unipolar depression, and has promise as an easily disseminable psychological intervention for bipolar depression. Using a randomised multiple baseline case series design we examined the feasibility and acceptability of an adapted version of BA in a U.K. outpatient sample of 12 adults with acute bipolar depression. Participants were allocated at random to a 3–8 week wait period before being offered up to 20 sessions of BA. They completed outcome measures at intake, pre- and post-treatment and weekly symptom measures across the study period. Retention in therapy was high (11/12 participants completed the target minimum number of sessions), and all participants returning acceptability measures reported high levels of satisfaction with the intervention. No therapy-related serious adverse events were reported, nor were there exacerbations in manic symptoms that were judged to be a result of the intervention. The pattern of change on outcome measures is consistent with the potential for clinical benefit; six of the nine participants with a stable baseline showed clinically significant improvement on the primary outcome measure. The findings suggest adapted BA for bipolar depression is a feasible and acceptable approach that merits further investigation. MDPI 2022-10-19 /pmc/articles/PMC9599144/ /pubmed/36291340 http://dx.doi.org/10.3390/brainsci12101407 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wright, Kim
Mostazir, Mohammod
Bailey, Ella
Dunn, Barnaby D.
O’Mahen, Heather
Sibsey, Michaela
Thomas, Zoe
Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series
title Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series
title_full Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series
title_fullStr Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series
title_full_unstemmed Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series
title_short Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series
title_sort adapted behavioural activation for bipolar depression: a randomised multiple baseline case series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599144/
https://www.ncbi.nlm.nih.gov/pubmed/36291340
http://dx.doi.org/10.3390/brainsci12101407
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