Cargando…

Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness

Psychotic disorders as well as psychosis proneness in the general population have been associated with perceptual instability, suggesting weakened predictive processing. Sleep disturbances play a prominent role in psychosis and schizophrenia, but it is unclear whether perceptual stability diminishes...

Descripción completa

Detalles Bibliográficos
Autores principales: Balter, Leonie J. T., Matheson, Granville J., Sundelin, Tina, Sterzer, Philipp, Petrovic, Predrag, Axelsson, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599202/
https://www.ncbi.nlm.nih.gov/pubmed/36291272
http://dx.doi.org/10.3390/brainsci12101338
_version_ 1784816537594494976
author Balter, Leonie J. T.
Matheson, Granville J.
Sundelin, Tina
Sterzer, Philipp
Petrovic, Predrag
Axelsson, John
author_facet Balter, Leonie J. T.
Matheson, Granville J.
Sundelin, Tina
Sterzer, Philipp
Petrovic, Predrag
Axelsson, John
author_sort Balter, Leonie J. T.
collection PubMed
description Psychotic disorders as well as psychosis proneness in the general population have been associated with perceptual instability, suggesting weakened predictive processing. Sleep disturbances play a prominent role in psychosis and schizophrenia, but it is unclear whether perceptual stability diminishes with sleep deprivation, and whether the effects of sleep deprivation differ as a function of psychosis proneness. In the current study, we aimed to clarify this matter. In this preregistered study, 146 participants successfully completed an intermittent version of the random dot kinematogram (RDK) task and the 21-item Peters Delusion Inventory (PDI-21) to assess perceptual stability and psychosis proneness, respectively. Participants were randomized to sleep either as normal (8 to 9 h in bed) (n = 72; M(age) = 24.7, SD = 6.2, 41 women) or to stay awake through the night (n = 74; M(age) = 24.8, SD = 5.1, 44 women). Sleep deprivation resulted in diminished perceptual stability, as well as in decreases in perceptual stability over the course of the task. However, we did not observe any association between perceptual stability and PDI-21 scores, nor a tendency for individuals with higher PDI-21 scores to be more vulnerable to sleep-deprivation-induced decreases in perceptual stability. The present study suggests a compromised predictive processing system in the brain after sleep deprivation, but variation in psychosis trait is not related to greater vulnerability to sleep deprivation in our dataset. Further studies in risk groups and patients with psychosis are needed to evaluate whether sleep loss plays a role in the occurrence of objectively measured perceptual-related clinical symptoms.
format Online
Article
Text
id pubmed-9599202
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95992022022-10-27 Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness Balter, Leonie J. T. Matheson, Granville J. Sundelin, Tina Sterzer, Philipp Petrovic, Predrag Axelsson, John Brain Sci Article Psychotic disorders as well as psychosis proneness in the general population have been associated with perceptual instability, suggesting weakened predictive processing. Sleep disturbances play a prominent role in psychosis and schizophrenia, but it is unclear whether perceptual stability diminishes with sleep deprivation, and whether the effects of sleep deprivation differ as a function of psychosis proneness. In the current study, we aimed to clarify this matter. In this preregistered study, 146 participants successfully completed an intermittent version of the random dot kinematogram (RDK) task and the 21-item Peters Delusion Inventory (PDI-21) to assess perceptual stability and psychosis proneness, respectively. Participants were randomized to sleep either as normal (8 to 9 h in bed) (n = 72; M(age) = 24.7, SD = 6.2, 41 women) or to stay awake through the night (n = 74; M(age) = 24.8, SD = 5.1, 44 women). Sleep deprivation resulted in diminished perceptual stability, as well as in decreases in perceptual stability over the course of the task. However, we did not observe any association between perceptual stability and PDI-21 scores, nor a tendency for individuals with higher PDI-21 scores to be more vulnerable to sleep-deprivation-induced decreases in perceptual stability. The present study suggests a compromised predictive processing system in the brain after sleep deprivation, but variation in psychosis trait is not related to greater vulnerability to sleep deprivation in our dataset. Further studies in risk groups and patients with psychosis are needed to evaluate whether sleep loss plays a role in the occurrence of objectively measured perceptual-related clinical symptoms. MDPI 2022-10-03 /pmc/articles/PMC9599202/ /pubmed/36291272 http://dx.doi.org/10.3390/brainsci12101338 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balter, Leonie J. T.
Matheson, Granville J.
Sundelin, Tina
Sterzer, Philipp
Petrovic, Predrag
Axelsson, John
Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness
title Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness
title_full Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness
title_fullStr Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness
title_full_unstemmed Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness
title_short Experimental Sleep Deprivation Results in Diminished Perceptual Stability Independently of Psychosis Proneness
title_sort experimental sleep deprivation results in diminished perceptual stability independently of psychosis proneness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599202/
https://www.ncbi.nlm.nih.gov/pubmed/36291272
http://dx.doi.org/10.3390/brainsci12101338
work_keys_str_mv AT balterleoniejt experimentalsleepdeprivationresultsindiminishedperceptualstabilityindependentlyofpsychosisproneness
AT mathesongranvillej experimentalsleepdeprivationresultsindiminishedperceptualstabilityindependentlyofpsychosisproneness
AT sundelintina experimentalsleepdeprivationresultsindiminishedperceptualstabilityindependentlyofpsychosisproneness
AT sterzerphilipp experimentalsleepdeprivationresultsindiminishedperceptualstabilityindependentlyofpsychosisproneness
AT petrovicpredrag experimentalsleepdeprivationresultsindiminishedperceptualstabilityindependentlyofpsychosisproneness
AT axelssonjohn experimentalsleepdeprivationresultsindiminishedperceptualstabilityindependentlyofpsychosisproneness