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Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis

(1) Background: We sought to investigate the impact of the COVID-19 pandemic in patients with lupus nephritis (LN); (2) Methods: A total of 95 patients with LN actively monitored in our department between 26 February 2020, when the first case of COVID-19 was diagnosed in Romania, and 1 May 2021, wer...

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Autores principales: Obrișcă, Bogdan, Vornicu, Alexandra, Jurubiță, Roxana, Mocanu, Valentin, Dimofte, George, Andronesi, Andreea, Sorohan, Bogdan, Achim, Camelia, Micu, Georgia, Bobeică, Raluca, Dina, Constantin, Ismail, Gener
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599215/
https://www.ncbi.nlm.nih.gov/pubmed/36289685
http://dx.doi.org/10.3390/biomedicines10102423
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author Obrișcă, Bogdan
Vornicu, Alexandra
Jurubiță, Roxana
Mocanu, Valentin
Dimofte, George
Andronesi, Andreea
Sorohan, Bogdan
Achim, Camelia
Micu, Georgia
Bobeică, Raluca
Dina, Constantin
Ismail, Gener
author_facet Obrișcă, Bogdan
Vornicu, Alexandra
Jurubiță, Roxana
Mocanu, Valentin
Dimofte, George
Andronesi, Andreea
Sorohan, Bogdan
Achim, Camelia
Micu, Georgia
Bobeică, Raluca
Dina, Constantin
Ismail, Gener
author_sort Obrișcă, Bogdan
collection PubMed
description (1) Background: We sought to investigate the impact of the COVID-19 pandemic in patients with lupus nephritis (LN); (2) Methods: A total of 95 patients with LN actively monitored in our department between 26 February 2020, when the first case of COVID-19 was diagnosed in Romania, and 1 May 2021, were included in the study. Multivariate logistic regression analysis was performed to identify the independent risk factors for SARS-CoV-2 infection; (3) Results: A total of 15 patients (15.8%) had a confirmed SARS-CoV-2 infection during a total follow-up time of 105.9 patient-years (unadjusted incidence rate: 14.28 SARS-CoV-2 infections per 100 patient-years). Median time to SARS-CoV-2 infection was 9.3 months (IQR: 7.2–11.3). The majority of patients had a mild form of SARS-CoV-2 infection (73.3%), while the remaining had moderate forms. None of the patients had a severe infection or a SARS-CoV-2-related death. The most frequent symptom was fatigue (73.3%), followed by loss of taste/smell (53.3%) and fever (46.7%). Forty percent of those with SARS-CoV-2 infection were hospitalized for a median 11.5 days (IQR:3.75–14). In the multivariate logistic regression analysis, a current oral corticosteroid dose ≥ 15 mg/day was associated with a 7.69-fold higher risk (OR, 7.69; 95%, 1.3–45.46), while the use of hydroxychloroquine was associated with a 91% lower risk for a SARS-CoV-2 infection (OR, 0.09; 95%CI, 0.01–0.59). (4) Conclusions: Our study confirms that the SARS-CoV-2 infection-associated morbidity might only be moderately increased in patients with LN. The current oral corticosteroid dose was the only independent predictor of infection occurrence, while use of hydroxychloroquine was associated with a protective effect.
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spelling pubmed-95992152022-10-27 Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis Obrișcă, Bogdan Vornicu, Alexandra Jurubiță, Roxana Mocanu, Valentin Dimofte, George Andronesi, Andreea Sorohan, Bogdan Achim, Camelia Micu, Georgia Bobeică, Raluca Dina, Constantin Ismail, Gener Biomedicines Article (1) Background: We sought to investigate the impact of the COVID-19 pandemic in patients with lupus nephritis (LN); (2) Methods: A total of 95 patients with LN actively monitored in our department between 26 February 2020, when the first case of COVID-19 was diagnosed in Romania, and 1 May 2021, were included in the study. Multivariate logistic regression analysis was performed to identify the independent risk factors for SARS-CoV-2 infection; (3) Results: A total of 15 patients (15.8%) had a confirmed SARS-CoV-2 infection during a total follow-up time of 105.9 patient-years (unadjusted incidence rate: 14.28 SARS-CoV-2 infections per 100 patient-years). Median time to SARS-CoV-2 infection was 9.3 months (IQR: 7.2–11.3). The majority of patients had a mild form of SARS-CoV-2 infection (73.3%), while the remaining had moderate forms. None of the patients had a severe infection or a SARS-CoV-2-related death. The most frequent symptom was fatigue (73.3%), followed by loss of taste/smell (53.3%) and fever (46.7%). Forty percent of those with SARS-CoV-2 infection were hospitalized for a median 11.5 days (IQR:3.75–14). In the multivariate logistic regression analysis, a current oral corticosteroid dose ≥ 15 mg/day was associated with a 7.69-fold higher risk (OR, 7.69; 95%, 1.3–45.46), while the use of hydroxychloroquine was associated with a 91% lower risk for a SARS-CoV-2 infection (OR, 0.09; 95%CI, 0.01–0.59). (4) Conclusions: Our study confirms that the SARS-CoV-2 infection-associated morbidity might only be moderately increased in patients with LN. The current oral corticosteroid dose was the only independent predictor of infection occurrence, while use of hydroxychloroquine was associated with a protective effect. MDPI 2022-09-28 /pmc/articles/PMC9599215/ /pubmed/36289685 http://dx.doi.org/10.3390/biomedicines10102423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Obrișcă, Bogdan
Vornicu, Alexandra
Jurubiță, Roxana
Mocanu, Valentin
Dimofte, George
Andronesi, Andreea
Sorohan, Bogdan
Achim, Camelia
Micu, Georgia
Bobeică, Raluca
Dina, Constantin
Ismail, Gener
Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis
title Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis
title_full Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis
title_fullStr Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis
title_full_unstemmed Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis
title_short Characteristics of SARS-CoV-2 Infection in an Actively Monitored Cohort of Patients with Lupus Nephritis
title_sort characteristics of sars-cov-2 infection in an actively monitored cohort of patients with lupus nephritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599215/
https://www.ncbi.nlm.nih.gov/pubmed/36289685
http://dx.doi.org/10.3390/biomedicines10102423
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