The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility

While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabol...

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Detalles Bibliográficos
Autores principales: Comas-Armangue, Gemma, Makharadze, Lela, Gomez-Velazquez, Melisa, Teperino, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599218/
https://www.ncbi.nlm.nih.gov/pubmed/36289722
http://dx.doi.org/10.3390/biomedicines10102461
Descripción
Sumario:While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures.

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