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Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity
It is important for clinicians to consider exposure to toxic substances and nutritional deficiencies when diagnosing and managing cases of vision loss. In these cases, physiologic damage can alter the function of key components of the visual pathway before morphologic changes can be detected by trad...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599231/ https://www.ncbi.nlm.nih.gov/pubmed/36291599 http://dx.doi.org/10.3390/biom12101390 |
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author | Chiang, Tsun-Kang White, Kayla Marie Kurup, Shree K. Yu, Minzhong |
author_facet | Chiang, Tsun-Kang White, Kayla Marie Kurup, Shree K. Yu, Minzhong |
author_sort | Chiang, Tsun-Kang |
collection | PubMed |
description | It is important for clinicians to consider exposure to toxic substances and nutritional deficiencies when diagnosing and managing cases of vision loss. In these cases, physiologic damage can alter the function of key components of the visual pathway before morphologic changes can be detected by traditional imaging methods. Electrophysiologic tests can aid in the early detection of such functional changes to visual pathway components, including the retina or optic nerve. This review provides an overview of various electrophysiologic techniques, including multifocal electroretinogram (mfERG), full-field ERG (ffERG), electrooculogram (EOG), pattern electroretinogram (PERG), and visual evoked potential (VEP) in monitoring the retinal and optic nerve toxicities of alcohol, amiodarone, cefuroxime, cisplatin, deferoxamine, digoxin, ethambutol, hydroxychloroquine, isotretinoin, ocular siderosis, pentosane, PDE5 inhibitors, phenothiazines (chlorpromazine and thioridazine), quinine, tamoxifen, topiramate, vigabatrin, and vitamin A deficiency. |
format | Online Article Text |
id | pubmed-9599231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95992312022-10-27 Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity Chiang, Tsun-Kang White, Kayla Marie Kurup, Shree K. Yu, Minzhong Biomolecules Review It is important for clinicians to consider exposure to toxic substances and nutritional deficiencies when diagnosing and managing cases of vision loss. In these cases, physiologic damage can alter the function of key components of the visual pathway before morphologic changes can be detected by traditional imaging methods. Electrophysiologic tests can aid in the early detection of such functional changes to visual pathway components, including the retina or optic nerve. This review provides an overview of various electrophysiologic techniques, including multifocal electroretinogram (mfERG), full-field ERG (ffERG), electrooculogram (EOG), pattern electroretinogram (PERG), and visual evoked potential (VEP) in monitoring the retinal and optic nerve toxicities of alcohol, amiodarone, cefuroxime, cisplatin, deferoxamine, digoxin, ethambutol, hydroxychloroquine, isotretinoin, ocular siderosis, pentosane, PDE5 inhibitors, phenothiazines (chlorpromazine and thioridazine), quinine, tamoxifen, topiramate, vigabatrin, and vitamin A deficiency. MDPI 2022-09-29 /pmc/articles/PMC9599231/ /pubmed/36291599 http://dx.doi.org/10.3390/biom12101390 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chiang, Tsun-Kang White, Kayla Marie Kurup, Shree K. Yu, Minzhong Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity |
title | Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity |
title_full | Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity |
title_fullStr | Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity |
title_full_unstemmed | Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity |
title_short | Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity |
title_sort | use of visual electrophysiology to monitor retinal and optic nerve toxicity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599231/ https://www.ncbi.nlm.nih.gov/pubmed/36291599 http://dx.doi.org/10.3390/biom12101390 |
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