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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish

Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning. A critical pluripotency transcriptional gene circuit of sox2, pou5f1 (oct4;...

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Autores principales: Manikandan, Priyadharshini, Sarmah, Swapnalee, Marrs, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599251/
https://www.ncbi.nlm.nih.gov/pubmed/36289818
http://dx.doi.org/10.3390/biomedicines10102555
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author Manikandan, Priyadharshini
Sarmah, Swapnalee
Marrs, James A.
author_facet Manikandan, Priyadharshini
Sarmah, Swapnalee
Marrs, James A.
author_sort Manikandan, Priyadharshini
collection PubMed
description Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning. A critical pluripotency transcriptional gene circuit of sox2, pou5f1 (oct4; recently renamed pou5f3), and nanog maintain potency and self-renewal. Ethanol affects sox2 expression, which functions with pou5f1 to control target gene transcription. Various genes, like elf3, may interact and regulate sox2, and elf3 knockdown affects early development. Downstream of the pluripotency transcriptional circuit, developmental signaling activities regulate morphogenetic cell movements and lineage specification. These activities are also affected by ethanol exposure. Hedgehog signaling is a critical developmental signaling pathway that controls numerous developmental events, including neural axis specification. Sonic hedgehog activities are affected by embryonic ethanol exposure. Activation of sonic hedgehog expression is controlled by TGF-ß family members, Nodal and Bmp, during dorsoventral (DV) embryonic axis establishment. Ethanol may perturb TGF-ß family receptors and signaling activities, including the sonic hedgehog pathway. Significantly, experiments show that activation of sonic hedgehog signaling rescues some embryonic ethanol exposure effects. More research is needed to understand how ethanol affects early developmental signaling and morphogenesis.
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spelling pubmed-95992512022-10-27 Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish Manikandan, Priyadharshini Sarmah, Swapnalee Marrs, James A. Biomedicines Review Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning. A critical pluripotency transcriptional gene circuit of sox2, pou5f1 (oct4; recently renamed pou5f3), and nanog maintain potency and self-renewal. Ethanol affects sox2 expression, which functions with pou5f1 to control target gene transcription. Various genes, like elf3, may interact and regulate sox2, and elf3 knockdown affects early development. Downstream of the pluripotency transcriptional circuit, developmental signaling activities regulate morphogenetic cell movements and lineage specification. These activities are also affected by ethanol exposure. Hedgehog signaling is a critical developmental signaling pathway that controls numerous developmental events, including neural axis specification. Sonic hedgehog activities are affected by embryonic ethanol exposure. Activation of sonic hedgehog expression is controlled by TGF-ß family members, Nodal and Bmp, during dorsoventral (DV) embryonic axis establishment. Ethanol may perturb TGF-ß family receptors and signaling activities, including the sonic hedgehog pathway. Significantly, experiments show that activation of sonic hedgehog signaling rescues some embryonic ethanol exposure effects. More research is needed to understand how ethanol affects early developmental signaling and morphogenesis. MDPI 2022-10-13 /pmc/articles/PMC9599251/ /pubmed/36289818 http://dx.doi.org/10.3390/biomedicines10102555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manikandan, Priyadharshini
Sarmah, Swapnalee
Marrs, James A.
Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
title Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
title_full Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
title_fullStr Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
title_full_unstemmed Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
title_short Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
title_sort ethanol effects on early developmental stages studied using the zebrafish
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599251/
https://www.ncbi.nlm.nih.gov/pubmed/36289818
http://dx.doi.org/10.3390/biomedicines10102555
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