Cargando…

Safety of Clinical Ultrasound Neuromodulation

Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received muc...

Descripción completa

Detalles Bibliográficos
Autores principales: Radjenovic, Sonja, Dörl, Gregor, Gaal, Martin, Beisteiner, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599299/
https://www.ncbi.nlm.nih.gov/pubmed/36291211
http://dx.doi.org/10.3390/brainsci12101277
_version_ 1784816560712450048
author Radjenovic, Sonja
Dörl, Gregor
Gaal, Martin
Beisteiner, Roland
author_facet Radjenovic, Sonja
Dörl, Gregor
Gaal, Martin
Beisteiner, Roland
author_sort Radjenovic, Sonja
collection PubMed
description Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received much interest, clinical applications are still relatively scarce. For safety considerations, the current literature is largely based on guidelines for ultrasound imaging that uses various physical parameters to describe the ultrasound pulse form and expected bioeffects. However, the safety situation for neuromodulation is inherently different. This article provides an overview of relevant ultrasound parameters with a focus on bioeffects relevant for safe clinical applications. Further, a retrospective analysis of safety data for clinical TPS applications in patients is presented.
format Online
Article
Text
id pubmed-9599299
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95992992022-10-27 Safety of Clinical Ultrasound Neuromodulation Radjenovic, Sonja Dörl, Gregor Gaal, Martin Beisteiner, Roland Brain Sci Review Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received much interest, clinical applications are still relatively scarce. For safety considerations, the current literature is largely based on guidelines for ultrasound imaging that uses various physical parameters to describe the ultrasound pulse form and expected bioeffects. However, the safety situation for neuromodulation is inherently different. This article provides an overview of relevant ultrasound parameters with a focus on bioeffects relevant for safe clinical applications. Further, a retrospective analysis of safety data for clinical TPS applications in patients is presented. MDPI 2022-09-22 /pmc/articles/PMC9599299/ /pubmed/36291211 http://dx.doi.org/10.3390/brainsci12101277 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Radjenovic, Sonja
Dörl, Gregor
Gaal, Martin
Beisteiner, Roland
Safety of Clinical Ultrasound Neuromodulation
title Safety of Clinical Ultrasound Neuromodulation
title_full Safety of Clinical Ultrasound Neuromodulation
title_fullStr Safety of Clinical Ultrasound Neuromodulation
title_full_unstemmed Safety of Clinical Ultrasound Neuromodulation
title_short Safety of Clinical Ultrasound Neuromodulation
title_sort safety of clinical ultrasound neuromodulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599299/
https://www.ncbi.nlm.nih.gov/pubmed/36291211
http://dx.doi.org/10.3390/brainsci12101277
work_keys_str_mv AT radjenovicsonja safetyofclinicalultrasoundneuromodulation
AT dorlgregor safetyofclinicalultrasoundneuromodulation
AT gaalmartin safetyofclinicalultrasoundneuromodulation
AT beisteinerroland safetyofclinicalultrasoundneuromodulation