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Safety of Clinical Ultrasound Neuromodulation
Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received muc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599299/ https://www.ncbi.nlm.nih.gov/pubmed/36291211 http://dx.doi.org/10.3390/brainsci12101277 |
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author | Radjenovic, Sonja Dörl, Gregor Gaal, Martin Beisteiner, Roland |
author_facet | Radjenovic, Sonja Dörl, Gregor Gaal, Martin Beisteiner, Roland |
author_sort | Radjenovic, Sonja |
collection | PubMed |
description | Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received much interest, clinical applications are still relatively scarce. For safety considerations, the current literature is largely based on guidelines for ultrasound imaging that uses various physical parameters to describe the ultrasound pulse form and expected bioeffects. However, the safety situation for neuromodulation is inherently different. This article provides an overview of relevant ultrasound parameters with a focus on bioeffects relevant for safe clinical applications. Further, a retrospective analysis of safety data for clinical TPS applications in patients is presented. |
format | Online Article Text |
id | pubmed-9599299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95992992022-10-27 Safety of Clinical Ultrasound Neuromodulation Radjenovic, Sonja Dörl, Gregor Gaal, Martin Beisteiner, Roland Brain Sci Review Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received much interest, clinical applications are still relatively scarce. For safety considerations, the current literature is largely based on guidelines for ultrasound imaging that uses various physical parameters to describe the ultrasound pulse form and expected bioeffects. However, the safety situation for neuromodulation is inherently different. This article provides an overview of relevant ultrasound parameters with a focus on bioeffects relevant for safe clinical applications. Further, a retrospective analysis of safety data for clinical TPS applications in patients is presented. MDPI 2022-09-22 /pmc/articles/PMC9599299/ /pubmed/36291211 http://dx.doi.org/10.3390/brainsci12101277 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Radjenovic, Sonja Dörl, Gregor Gaal, Martin Beisteiner, Roland Safety of Clinical Ultrasound Neuromodulation |
title | Safety of Clinical Ultrasound Neuromodulation |
title_full | Safety of Clinical Ultrasound Neuromodulation |
title_fullStr | Safety of Clinical Ultrasound Neuromodulation |
title_full_unstemmed | Safety of Clinical Ultrasound Neuromodulation |
title_short | Safety of Clinical Ultrasound Neuromodulation |
title_sort | safety of clinical ultrasound neuromodulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599299/ https://www.ncbi.nlm.nih.gov/pubmed/36291211 http://dx.doi.org/10.3390/brainsci12101277 |
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