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Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease

Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected...

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Autores principales: Yu, Tengfei, Wang, Rong, Ye, Xun, Zeng, Chun, Chen, Xiaolin, Zhao, Yuanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599360/
https://www.ncbi.nlm.nih.gov/pubmed/36291204
http://dx.doi.org/10.3390/brainsci12101270
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author Yu, Tengfei
Wang, Rong
Ye, Xun
Zeng, Chun
Chen, Xiaolin
Zhao, Yuanli
author_facet Yu, Tengfei
Wang, Rong
Ye, Xun
Zeng, Chun
Chen, Xiaolin
Zhao, Yuanli
author_sort Yu, Tengfei
collection PubMed
description Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis. Results: Age (OR, 0.969; 95%CI, 0.939–1.000; p = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730–19.732; p = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079–18.526; p = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452–13.129; p = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427–19.948; p = 0.013), TIA (OR, 4.264; 95%CI, 1.844–9.863; p = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194–7.397; p = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%. Conclusions: Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD.
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spelling pubmed-95993602022-10-27 Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease Yu, Tengfei Wang, Rong Ye, Xun Zeng, Chun Chen, Xiaolin Zhao, Yuanli Brain Sci Article Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis. Results: Age (OR, 0.969; 95%CI, 0.939–1.000; p = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730–19.732; p = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079–18.526; p = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452–13.129; p = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427–19.948; p = 0.013), TIA (OR, 4.264; 95%CI, 1.844–9.863; p = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194–7.397; p = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%. Conclusions: Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD. MDPI 2022-09-20 /pmc/articles/PMC9599360/ /pubmed/36291204 http://dx.doi.org/10.3390/brainsci12101270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Tengfei
Wang, Rong
Ye, Xun
Zeng, Chun
Chen, Xiaolin
Zhao, Yuanli
Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
title Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
title_full Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
title_fullStr Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
title_full_unstemmed Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
title_short Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
title_sort angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599360/
https://www.ncbi.nlm.nih.gov/pubmed/36291204
http://dx.doi.org/10.3390/brainsci12101270
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