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Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease
Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599360/ https://www.ncbi.nlm.nih.gov/pubmed/36291204 http://dx.doi.org/10.3390/brainsci12101270 |
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author | Yu, Tengfei Wang, Rong Ye, Xun Zeng, Chun Chen, Xiaolin Zhao, Yuanli |
author_facet | Yu, Tengfei Wang, Rong Ye, Xun Zeng, Chun Chen, Xiaolin Zhao, Yuanli |
author_sort | Yu, Tengfei |
collection | PubMed |
description | Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis. Results: Age (OR, 0.969; 95%CI, 0.939–1.000; p = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730–19.732; p = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079–18.526; p = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452–13.129; p = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427–19.948; p = 0.013), TIA (OR, 4.264; 95%CI, 1.844–9.863; p = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194–7.397; p = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%. Conclusions: Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD. |
format | Online Article Text |
id | pubmed-9599360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95993602022-10-27 Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease Yu, Tengfei Wang, Rong Ye, Xun Zeng, Chun Chen, Xiaolin Zhao, Yuanli Brain Sci Article Objective: To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease. Methods: Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis. Results: Age (OR, 0.969; 95%CI, 0.939–1.000; p = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730–19.732; p = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079–18.526; p = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452–13.129; p = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427–19.948; p = 0.013), TIA (OR, 4.264; 95%CI, 1.844–9.863; p = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194–7.397; p = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%. Conclusions: Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD. MDPI 2022-09-20 /pmc/articles/PMC9599360/ /pubmed/36291204 http://dx.doi.org/10.3390/brainsci12101270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yu, Tengfei Wang, Rong Ye, Xun Zeng, Chun Chen, Xiaolin Zhao, Yuanli Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
title | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
title_full | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
title_fullStr | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
title_full_unstemmed | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
title_short | Angioarchitectural Factors Associated with Postoperative Cerebral Infarction in Ischemic Moyamoya Disease |
title_sort | angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599360/ https://www.ncbi.nlm.nih.gov/pubmed/36291204 http://dx.doi.org/10.3390/brainsci12101270 |
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