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Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma

Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mi...

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Autores principales: Huang, Chiang-Chi, Liu, Hui-Ying, Hsu, Tsuen-Wei, Lee, Wen-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599371/
https://www.ncbi.nlm.nih.gov/pubmed/36289714
http://dx.doi.org/10.3390/biomedicines10102453
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author Huang, Chiang-Chi
Liu, Hui-Ying
Hsu, Tsuen-Wei
Lee, Wen-Chin
author_facet Huang, Chiang-Chi
Liu, Hui-Ying
Hsu, Tsuen-Wei
Lee, Wen-Chin
author_sort Huang, Chiang-Chi
collection PubMed
description Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mitochondria in urothelial carcinoma (UC), which is a major global health challenge. This review focuses on research advances in the role of mitochondria in UC. Here, we discuss the pathogenic roles of mitochondria in UC and update the mitochondria-targeted therapies. We aim to offer a better understanding of the mitochondria-modulated pathogenesis of UC and hope that this review will allow the development of novel mitochondria-targeted therapies.
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spelling pubmed-95993712022-10-27 Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma Huang, Chiang-Chi Liu, Hui-Ying Hsu, Tsuen-Wei Lee, Wen-Chin Biomedicines Review Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mitochondria in urothelial carcinoma (UC), which is a major global health challenge. This review focuses on research advances in the role of mitochondria in UC. Here, we discuss the pathogenic roles of mitochondria in UC and update the mitochondria-targeted therapies. We aim to offer a better understanding of the mitochondria-modulated pathogenesis of UC and hope that this review will allow the development of novel mitochondria-targeted therapies. MDPI 2022-10-01 /pmc/articles/PMC9599371/ /pubmed/36289714 http://dx.doi.org/10.3390/biomedicines10102453 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Chiang-Chi
Liu, Hui-Ying
Hsu, Tsuen-Wei
Lee, Wen-Chin
Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
title Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
title_full Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
title_fullStr Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
title_full_unstemmed Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
title_short Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
title_sort updates on the pivotal roles of mitochondria in urothelial carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599371/
https://www.ncbi.nlm.nih.gov/pubmed/36289714
http://dx.doi.org/10.3390/biomedicines10102453
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