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Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma
Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599371/ https://www.ncbi.nlm.nih.gov/pubmed/36289714 http://dx.doi.org/10.3390/biomedicines10102453 |
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author | Huang, Chiang-Chi Liu, Hui-Ying Hsu, Tsuen-Wei Lee, Wen-Chin |
author_facet | Huang, Chiang-Chi Liu, Hui-Ying Hsu, Tsuen-Wei Lee, Wen-Chin |
author_sort | Huang, Chiang-Chi |
collection | PubMed |
description | Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mitochondria in urothelial carcinoma (UC), which is a major global health challenge. This review focuses on research advances in the role of mitochondria in UC. Here, we discuss the pathogenic roles of mitochondria in UC and update the mitochondria-targeted therapies. We aim to offer a better understanding of the mitochondria-modulated pathogenesis of UC and hope that this review will allow the development of novel mitochondria-targeted therapies. |
format | Online Article Text |
id | pubmed-9599371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95993712022-10-27 Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma Huang, Chiang-Chi Liu, Hui-Ying Hsu, Tsuen-Wei Lee, Wen-Chin Biomedicines Review Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mitochondria in urothelial carcinoma (UC), which is a major global health challenge. This review focuses on research advances in the role of mitochondria in UC. Here, we discuss the pathogenic roles of mitochondria in UC and update the mitochondria-targeted therapies. We aim to offer a better understanding of the mitochondria-modulated pathogenesis of UC and hope that this review will allow the development of novel mitochondria-targeted therapies. MDPI 2022-10-01 /pmc/articles/PMC9599371/ /pubmed/36289714 http://dx.doi.org/10.3390/biomedicines10102453 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Huang, Chiang-Chi Liu, Hui-Ying Hsu, Tsuen-Wei Lee, Wen-Chin Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma |
title | Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma |
title_full | Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma |
title_fullStr | Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma |
title_full_unstemmed | Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma |
title_short | Updates on the Pivotal Roles of Mitochondria in Urothelial Carcinoma |
title_sort | updates on the pivotal roles of mitochondria in urothelial carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599371/ https://www.ncbi.nlm.nih.gov/pubmed/36289714 http://dx.doi.org/10.3390/biomedicines10102453 |
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