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Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis agains...

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Autores principales: Khudiakova, Alena Dmitrievna, Polonskaya, Yana Vladimirovna, Shramko, Victoria Sergeevna, Shcherbakova, Lilia Valeryevna, Striukova, Evgeniia Vitalievna, Kashtanova, Elena Vladimirovna, Ragino, Yulia Igorevna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599484/
https://www.ncbi.nlm.nih.gov/pubmed/36291711
http://dx.doi.org/10.3390/biom12101502
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author Khudiakova, Alena Dmitrievna
Polonskaya, Yana Vladimirovna
Shramko, Victoria Sergeevna
Shcherbakova, Lilia Valeryevna
Striukova, Evgeniia Vitalievna
Kashtanova, Elena Vladimirovna
Ragino, Yulia Igorevna
author_facet Khudiakova, Alena Dmitrievna
Polonskaya, Yana Vladimirovna
Shramko, Victoria Sergeevna
Shcherbakova, Lilia Valeryevna
Striukova, Evgeniia Vitalievna
Kashtanova, Elena Vladimirovna
Ragino, Yulia Igorevna
author_sort Khudiakova, Alena Dmitrievna
collection PubMed
description The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa.
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spelling pubmed-95994842022-10-27 Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity Khudiakova, Alena Dmitrievna Polonskaya, Yana Vladimirovna Shramko, Victoria Sergeevna Shcherbakova, Lilia Valeryevna Striukova, Evgeniia Vitalievna Kashtanova, Elena Vladimirovna Ragino, Yulia Igorevna Biomolecules Article The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa. MDPI 2022-10-17 /pmc/articles/PMC9599484/ /pubmed/36291711 http://dx.doi.org/10.3390/biom12101502 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khudiakova, Alena Dmitrievna
Polonskaya, Yana Vladimirovna
Shramko, Victoria Sergeevna
Shcherbakova, Lilia Valeryevna
Striukova, Evgeniia Vitalievna
Kashtanova, Elena Vladimirovna
Ragino, Yulia Igorevna
Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
title Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
title_full Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
title_fullStr Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
title_full_unstemmed Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
title_short Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
title_sort blood adipokines/cytokines in young people with chronic bronchitis and abdominal obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599484/
https://www.ncbi.nlm.nih.gov/pubmed/36291711
http://dx.doi.org/10.3390/biom12101502
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