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Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis agains...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599484/ https://www.ncbi.nlm.nih.gov/pubmed/36291711 http://dx.doi.org/10.3390/biom12101502 |
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author | Khudiakova, Alena Dmitrievna Polonskaya, Yana Vladimirovna Shramko, Victoria Sergeevna Shcherbakova, Lilia Valeryevna Striukova, Evgeniia Vitalievna Kashtanova, Elena Vladimirovna Ragino, Yulia Igorevna |
author_facet | Khudiakova, Alena Dmitrievna Polonskaya, Yana Vladimirovna Shramko, Victoria Sergeevna Shcherbakova, Lilia Valeryevna Striukova, Evgeniia Vitalievna Kashtanova, Elena Vladimirovna Ragino, Yulia Igorevna |
author_sort | Khudiakova, Alena Dmitrievna |
collection | PubMed |
description | The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa. |
format | Online Article Text |
id | pubmed-9599484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95994842022-10-27 Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity Khudiakova, Alena Dmitrievna Polonskaya, Yana Vladimirovna Shramko, Victoria Sergeevna Shcherbakova, Lilia Valeryevna Striukova, Evgeniia Vitalievna Kashtanova, Elena Vladimirovna Ragino, Yulia Igorevna Biomolecules Article The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa. MDPI 2022-10-17 /pmc/articles/PMC9599484/ /pubmed/36291711 http://dx.doi.org/10.3390/biom12101502 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khudiakova, Alena Dmitrievna Polonskaya, Yana Vladimirovna Shramko, Victoria Sergeevna Shcherbakova, Lilia Valeryevna Striukova, Evgeniia Vitalievna Kashtanova, Elena Vladimirovna Ragino, Yulia Igorevna Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
title | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
title_full | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
title_fullStr | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
title_full_unstemmed | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
title_short | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
title_sort | blood adipokines/cytokines in young people with chronic bronchitis and abdominal obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599484/ https://www.ncbi.nlm.nih.gov/pubmed/36291711 http://dx.doi.org/10.3390/biom12101502 |
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