PHLPP Inhibitor NSC74429 Is Neuroprotective in Rodent Models of Cardiac Arrest and Traumatic Brain Injury

Pleckstrin homology domain and leucine rich repeat protein phosphatase (PHLPP) knockout mice have improved outcomes after a stroke, traumatic brain injury (TBI), and decreased maladaptive vascular remodeling following vascular injury. Thus, small-molecule PHLPP inhibitors have the potential to impro...

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Detalles Bibliográficos
Autores principales: Jackson, Travis C., Dezfulian, Cameron, Vagni, Vincent A., Stezoski, Jason, Janesko-Feldman, Keri, Kochanek, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599532/
https://www.ncbi.nlm.nih.gov/pubmed/36291561
http://dx.doi.org/10.3390/biom12101352

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