Cargando…
Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia
Background and Aims: Recent reports suggest that results from imaging retinal microvascular changes with optical coherence tomography angiography (OCTA) in dementia patients reflect cerebral microcirculation changes that occur during dementia. Macula microvascular impairment has been shown in dement...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599536/ https://www.ncbi.nlm.nih.gov/pubmed/36291324 http://dx.doi.org/10.3390/brainsci12101391 |
_version_ | 1784816618522542080 |
---|---|
author | Zhang, Ziyi Liu, Peng Kwapong, William Robert Wu, Bo Liu, Ming Zhang, Shuting |
author_facet | Zhang, Ziyi Liu, Peng Kwapong, William Robert Wu, Bo Liu, Ming Zhang, Shuting |
author_sort | Zhang, Ziyi |
collection | PubMed |
description | Background and Aims: Recent reports suggest that results from imaging retinal microvascular changes with optical coherence tomography angiography (OCTA) in dementia patients reflect cerebral microcirculation changes that occur during dementia. Macula microvascular impairment has been shown in dementia patients compared to controls, but very little is known about its correlation with radiological visual rating scores associated with dementia. We aimed to explore the association between retinal microvasculature and radiological visual rating in early-onset dementia (EOD) patients. Methods: Swept-source OCTA (SS-OCTA) was used to image the retinal microvasculature of all EOD patients. Automated software in the OCTA tool segmented and measured the densities in the superficial vascular plexus (SVC) and deep vascular plexus (DVC) and foveal avascular zone (FAZ) areas. Radiological visual rating scores were evaluated on all MR images. Results: Medial temporal lobe atrophy (MTA) scores significantly correlated with FAZ area (p = 0.031) in EOD patients after adjusting for risk factors. PWMH correlated with SVC (p = 0.032) while DWMH significantly correlated with SVC (p = 0.007), DVC (p = 0.018) and FAZ (p = 0.001) in EOD patients. Discussion: FAZ changes correlated with MTA scores in EOD patients, while retinal microvasculature correlated with white matter hyperintensity. Our report suggests that microvascular changes in the retina may reflect cortical changes in the brain of EOD patients. |
format | Online Article Text |
id | pubmed-9599536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95995362022-10-27 Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia Zhang, Ziyi Liu, Peng Kwapong, William Robert Wu, Bo Liu, Ming Zhang, Shuting Brain Sci Article Background and Aims: Recent reports suggest that results from imaging retinal microvascular changes with optical coherence tomography angiography (OCTA) in dementia patients reflect cerebral microcirculation changes that occur during dementia. Macula microvascular impairment has been shown in dementia patients compared to controls, but very little is known about its correlation with radiological visual rating scores associated with dementia. We aimed to explore the association between retinal microvasculature and radiological visual rating in early-onset dementia (EOD) patients. Methods: Swept-source OCTA (SS-OCTA) was used to image the retinal microvasculature of all EOD patients. Automated software in the OCTA tool segmented and measured the densities in the superficial vascular plexus (SVC) and deep vascular plexus (DVC) and foveal avascular zone (FAZ) areas. Radiological visual rating scores were evaluated on all MR images. Results: Medial temporal lobe atrophy (MTA) scores significantly correlated with FAZ area (p = 0.031) in EOD patients after adjusting for risk factors. PWMH correlated with SVC (p = 0.032) while DWMH significantly correlated with SVC (p = 0.007), DVC (p = 0.018) and FAZ (p = 0.001) in EOD patients. Discussion: FAZ changes correlated with MTA scores in EOD patients, while retinal microvasculature correlated with white matter hyperintensity. Our report suggests that microvascular changes in the retina may reflect cortical changes in the brain of EOD patients. MDPI 2022-10-14 /pmc/articles/PMC9599536/ /pubmed/36291324 http://dx.doi.org/10.3390/brainsci12101391 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Ziyi Liu, Peng Kwapong, William Robert Wu, Bo Liu, Ming Zhang, Shuting Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia |
title | Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia |
title_full | Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia |
title_fullStr | Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia |
title_full_unstemmed | Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia |
title_short | Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia |
title_sort | microvascular changes in the retina correlate with mri markers in patients with early-onset dementia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599536/ https://www.ncbi.nlm.nih.gov/pubmed/36291324 http://dx.doi.org/10.3390/brainsci12101391 |
work_keys_str_mv | AT zhangziyi microvascularchangesintheretinacorrelatewithmrimarkersinpatientswithearlyonsetdementia AT liupeng microvascularchangesintheretinacorrelatewithmrimarkersinpatientswithearlyonsetdementia AT kwapongwilliamrobert microvascularchangesintheretinacorrelatewithmrimarkersinpatientswithearlyonsetdementia AT wubo microvascularchangesintheretinacorrelatewithmrimarkersinpatientswithearlyonsetdementia AT liuming microvascularchangesintheretinacorrelatewithmrimarkersinpatientswithearlyonsetdementia AT zhangshuting microvascularchangesintheretinacorrelatewithmrimarkersinpatientswithearlyonsetdementia |