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Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases

Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to construct functional connectivity (FC) in the brain for the diagnosis and analysis of brain disease. Current studies typically use the Pearson correlation coefficient to construct dynamic FC (dFC) networks, and then use t...

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Autores principales: Gao, Libin, Hu, Zhongyi, Li, Rui, Lu, Xingjin, Li, Zuoyong, Zhang, Xiabin, Xu, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599611/
https://www.ncbi.nlm.nih.gov/pubmed/36291282
http://dx.doi.org/10.3390/brainsci12101348
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author Gao, Libin
Hu, Zhongyi
Li, Rui
Lu, Xingjin
Li, Zuoyong
Zhang, Xiabin
Xu, Shiwei
author_facet Gao, Libin
Hu, Zhongyi
Li, Rui
Lu, Xingjin
Li, Zuoyong
Zhang, Xiabin
Xu, Shiwei
author_sort Gao, Libin
collection PubMed
description Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to construct functional connectivity (FC) in the brain for the diagnosis and analysis of brain disease. Current studies typically use the Pearson correlation coefficient to construct dynamic FC (dFC) networks, and then use this as a network metric to obtain the necessary features for brain disease diagnosis and analysis. This simple observational approach makes it difficult to extract potential high-level FC features from the representations, and also ignores the rich information on spatial and temporal variability in FC. In this paper, we construct the Latent Space Representation Network (LSRNet) and use two stages to train the network. In the first stage, an autoencoder is used to extract potential high-level features and inner connections in the dFC representations. In the second stage, high-level features are extracted using two perspective feature parses. Long Short-Term Memory (LSTM) networks are used to extract spatial and temporal features from the local perspective. Convolutional neural networks extract global high-level features from the global perspective. Finally, the fusion of spatial and temporal features with global high-level features is used to diagnose brain disease. In this paper, the proposed method is applied to the ANDI rs-fMRI dataset, and the classification accuracy reaches 84.6% for NC/eMCI, 95.1% for NC/AD, 80.6% for eMCI/lMCI, 84.2% for lMCI/AD and 57.3% for NC/eMCI/lMCI/AD. The experimental results show that the method has a good classification performance and provides a new approach to the diagnosis of other brain diseases.
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spelling pubmed-95996112022-10-27 Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases Gao, Libin Hu, Zhongyi Li, Rui Lu, Xingjin Li, Zuoyong Zhang, Xiabin Xu, Shiwei Brain Sci Article Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to construct functional connectivity (FC) in the brain for the diagnosis and analysis of brain disease. Current studies typically use the Pearson correlation coefficient to construct dynamic FC (dFC) networks, and then use this as a network metric to obtain the necessary features for brain disease diagnosis and analysis. This simple observational approach makes it difficult to extract potential high-level FC features from the representations, and also ignores the rich information on spatial and temporal variability in FC. In this paper, we construct the Latent Space Representation Network (LSRNet) and use two stages to train the network. In the first stage, an autoencoder is used to extract potential high-level features and inner connections in the dFC representations. In the second stage, high-level features are extracted using two perspective feature parses. Long Short-Term Memory (LSTM) networks are used to extract spatial and temporal features from the local perspective. Convolutional neural networks extract global high-level features from the global perspective. Finally, the fusion of spatial and temporal features with global high-level features is used to diagnose brain disease. In this paper, the proposed method is applied to the ANDI rs-fMRI dataset, and the classification accuracy reaches 84.6% for NC/eMCI, 95.1% for NC/AD, 80.6% for eMCI/lMCI, 84.2% for lMCI/AD and 57.3% for NC/eMCI/lMCI/AD. The experimental results show that the method has a good classification performance and provides a new approach to the diagnosis of other brain diseases. MDPI 2022-10-05 /pmc/articles/PMC9599611/ /pubmed/36291282 http://dx.doi.org/10.3390/brainsci12101348 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gao, Libin
Hu, Zhongyi
Li, Rui
Lu, Xingjin
Li, Zuoyong
Zhang, Xiabin
Xu, Shiwei
Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases
title Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases
title_full Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases
title_fullStr Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases
title_full_unstemmed Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases
title_short Multi-Perspective Feature Extraction and Fusion Based on Deep Latent Space for Diagnosis of Alzheimer’s Diseases
title_sort multi-perspective feature extraction and fusion based on deep latent space for diagnosis of alzheimer’s diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599611/
https://www.ncbi.nlm.nih.gov/pubmed/36291282
http://dx.doi.org/10.3390/brainsci12101348
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