TNP Analogues Inhibit the Virulence Promoting IP(3-4) Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs that convert IP(3) to IP(8), provides a promising new target due to its impact on multiple, c...

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Detalles Bibliográficos
Autores principales: Desmarini, Desmarini, Truong, Daniel, Wilkinson-White, Lorna, Desphande, Chandrika, Torrado, Mario, Mackay, Joel P., Matthews, Jacqueline M., Sorrell, Tania C., Lev, Sophie, Thompson, Philip E., Djordjevic, Julianne Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599641/
https://www.ncbi.nlm.nih.gov/pubmed/36291735
http://dx.doi.org/10.3390/biom12101526

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