Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and associated with an increased risk of morbidity and mortality, primarily from cardiovascular and renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) are novel drugs for the treatment of type 2 D...

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Autores principales: Prandi, Francesca Romana, Barone, Lucy, Lecis, Dalgisio, Belli, Martina, Sergi, Domenico, Milite, Marialucia, Lerakis, Stamatios, Romeo, Francesco, Barillà, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599693/
https://www.ncbi.nlm.nih.gov/pubmed/36291558
http://dx.doi.org/10.3390/biom12101349
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author Prandi, Francesca Romana
Barone, Lucy
Lecis, Dalgisio
Belli, Martina
Sergi, Domenico
Milite, Marialucia
Lerakis, Stamatios
Romeo, Francesco
Barillà, Francesco
author_facet Prandi, Francesca Romana
Barone, Lucy
Lecis, Dalgisio
Belli, Martina
Sergi, Domenico
Milite, Marialucia
Lerakis, Stamatios
Romeo, Francesco
Barillà, Francesco
author_sort Prandi, Francesca Romana
collection PubMed
description Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and associated with an increased risk of morbidity and mortality, primarily from cardiovascular and renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) are novel drugs for the treatment of type 2 DM and heart failure (HF). SGLT2-Is mediate protective effects on both the renal and cardiovascular systems. This review addresses the current knowledge on the biomolecular mechanisms of the cardiorenal protective effects of SGLT2-Is, which appear to act mainly through non-glucose-mediated pathways. Cardiorenal protection mechanisms lead to reduced chronic renal disease progression and improved myocardial and coronary endothelial function. Concomitantly, it is possible to observe reflected changes in biomarkers linked with diabetic kidney disease and HF.
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spelling pubmed-95996932022-10-27 Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors Prandi, Francesca Romana Barone, Lucy Lecis, Dalgisio Belli, Martina Sergi, Domenico Milite, Marialucia Lerakis, Stamatios Romeo, Francesco Barillà, Francesco Biomolecules Review Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and associated with an increased risk of morbidity and mortality, primarily from cardiovascular and renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) are novel drugs for the treatment of type 2 DM and heart failure (HF). SGLT2-Is mediate protective effects on both the renal and cardiovascular systems. This review addresses the current knowledge on the biomolecular mechanisms of the cardiorenal protective effects of SGLT2-Is, which appear to act mainly through non-glucose-mediated pathways. Cardiorenal protection mechanisms lead to reduced chronic renal disease progression and improved myocardial and coronary endothelial function. Concomitantly, it is possible to observe reflected changes in biomarkers linked with diabetic kidney disease and HF. MDPI 2022-09-22 /pmc/articles/PMC9599693/ /pubmed/36291558 http://dx.doi.org/10.3390/biom12101349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Prandi, Francesca Romana
Barone, Lucy
Lecis, Dalgisio
Belli, Martina
Sergi, Domenico
Milite, Marialucia
Lerakis, Stamatios
Romeo, Francesco
Barillà, Francesco
Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors
title Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors
title_full Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors
title_fullStr Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors
title_full_unstemmed Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors
title_short Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors
title_sort biomolecular mechanisms of cardiorenal protection with sodium-glucose co-transporter 2 inhibitors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599693/
https://www.ncbi.nlm.nih.gov/pubmed/36291558
http://dx.doi.org/10.3390/biom12101349
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