Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update

Neutrophil extracellular traps (NETs) are net-like complexes expelled from neutrophils, composing cell-free deoxyribonucleic acid (DNA), histones, and neutrophil granule proteins. Besides capturing and eliminating pathogens, NETs also exacerbate the inflammatory response associated with various dise...

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Detalles Bibliográficos
Autores principales: Zeng, Jia, Wu, Min, Zhou, Yamei, Zhu, Manhui, Liu, Xiaojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599702/
https://www.ncbi.nlm.nih.gov/pubmed/36291649
http://dx.doi.org/10.3390/biom12101440
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author Zeng, Jia
Wu, Min
Zhou, Yamei
Zhu, Manhui
Liu, Xiaojuan
author_facet Zeng, Jia
Wu, Min
Zhou, Yamei
Zhu, Manhui
Liu, Xiaojuan
author_sort Zeng, Jia
collection PubMed
description Neutrophil extracellular traps (NETs) are net-like complexes expelled from neutrophils, composing cell-free deoxyribonucleic acid (DNA), histones, and neutrophil granule proteins. Besides capturing and eliminating pathogens, NETs also exacerbate the inflammatory response associated with various diseases, including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Currently, there are growing reports about NETs involved in the pathogenesis of ocular diseases. This review primarily focuses on the pathogenesis of NETs in the ophthalmology field, highlighting their importance in serving as potential targets for the therapy of ocular diseases.
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spelling pubmed-95997022022-10-27 Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update Zeng, Jia Wu, Min Zhou, Yamei Zhu, Manhui Liu, Xiaojuan Biomolecules Review Neutrophil extracellular traps (NETs) are net-like complexes expelled from neutrophils, composing cell-free deoxyribonucleic acid (DNA), histones, and neutrophil granule proteins. Besides capturing and eliminating pathogens, NETs also exacerbate the inflammatory response associated with various diseases, including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Currently, there are growing reports about NETs involved in the pathogenesis of ocular diseases. This review primarily focuses on the pathogenesis of NETs in the ophthalmology field, highlighting their importance in serving as potential targets for the therapy of ocular diseases. MDPI 2022-10-08 /pmc/articles/PMC9599702/ /pubmed/36291649 http://dx.doi.org/10.3390/biom12101440 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zeng, Jia
Wu, Min
Zhou, Yamei
Zhu, Manhui
Liu, Xiaojuan
Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update
title Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update
title_full Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update
title_fullStr Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update
title_full_unstemmed Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update
title_short Neutrophil Extracellular Traps (NETs) in Ocular Diseases: An Update
title_sort neutrophil extracellular traps (nets) in ocular diseases: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599702/
https://www.ncbi.nlm.nih.gov/pubmed/36291649
http://dx.doi.org/10.3390/biom12101440
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