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Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity
Most patients with bronchiectasis have a predominantly neutrophilic inflammatory profile, although other cells such as lymphocytes (as controllers of bronchial inflammation) and eosinophils also play a significant pathophysiological role. Easy-to-interpret blood biomarkers with a discriminative capa...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599714/ https://www.ncbi.nlm.nih.gov/pubmed/36291608 http://dx.doi.org/10.3390/biom12101399 |
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author | Martinez-García, Miguel Ángel Olveira, Casilda Girón, Rosa García-Clemente, Marta Máiz-Carro, Luis Sibila, Oriol Golpe, Rafael Méndez, Raúl Rodríguez Hermosa, Juan Luis Barreiro, Esther Prados, Concepción Rodríguez López, Juan de la Rosa, David |
author_facet | Martinez-García, Miguel Ángel Olveira, Casilda Girón, Rosa García-Clemente, Marta Máiz-Carro, Luis Sibila, Oriol Golpe, Rafael Méndez, Raúl Rodríguez Hermosa, Juan Luis Barreiro, Esther Prados, Concepción Rodríguez López, Juan de la Rosa, David |
author_sort | Martinez-García, Miguel Ángel |
collection | PubMed |
description | Most patients with bronchiectasis have a predominantly neutrophilic inflammatory profile, although other cells such as lymphocytes (as controllers of bronchial inflammation) and eosinophils also play a significant pathophysiological role. Easy-to-interpret blood biomarkers with a discriminative capacity for severity or prognosis are needed. The objective of this study was to assess whether the peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with different outcomes of severity in bronchiectasis. A total of 1369 patients with bronchiectasis from the Spanish Registry of Bronchiectasis were included. To compare groups, the sample was divided into increasing quartiles of NLR ratio. Correlations between quantitative variables were established using Pearson’s P test. A simple linear regression (with the value of exacerbations as a quantitative variable) was used to determine the independent relationship between the number and severity of exacerbations and the NLR ratio. The area under the curve (AUC)-ROC was used to determine the predictive capacity of the NLR for severe bronchiectasis, according to the different multidimensional scores. Mean age: 69 (15) years (66.3% of women). The mean NLR was 2.92 (2.03). A higher NLR was associated with more severe bronchiectasis (with an especially significant discriminative power for severe forms) according to the commonly used scores (FACED, E-FACED and BSI), as well as with poorer quality of life (SGRQ), more comorbidities (Charlson index), infection by pathogenic microorganisms, and greater application of treatment. Furthermore, the NLR correlated better with severity scores than other parameters of systemic inflammation. Finally, it was an independent predictor of the incident number and severity of exacerbations. In conclusion, the NLR is an inexpensive and easy-to-measure marker of systemic inflammation for determining severity and predicting exacerbations (especially the most severe) in patients with bronchiectasis. |
format | Online Article Text |
id | pubmed-9599714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95997142022-10-27 Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity Martinez-García, Miguel Ángel Olveira, Casilda Girón, Rosa García-Clemente, Marta Máiz-Carro, Luis Sibila, Oriol Golpe, Rafael Méndez, Raúl Rodríguez Hermosa, Juan Luis Barreiro, Esther Prados, Concepción Rodríguez López, Juan de la Rosa, David Biomolecules Article Most patients with bronchiectasis have a predominantly neutrophilic inflammatory profile, although other cells such as lymphocytes (as controllers of bronchial inflammation) and eosinophils also play a significant pathophysiological role. Easy-to-interpret blood biomarkers with a discriminative capacity for severity or prognosis are needed. The objective of this study was to assess whether the peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with different outcomes of severity in bronchiectasis. A total of 1369 patients with bronchiectasis from the Spanish Registry of Bronchiectasis were included. To compare groups, the sample was divided into increasing quartiles of NLR ratio. Correlations between quantitative variables were established using Pearson’s P test. A simple linear regression (with the value of exacerbations as a quantitative variable) was used to determine the independent relationship between the number and severity of exacerbations and the NLR ratio. The area under the curve (AUC)-ROC was used to determine the predictive capacity of the NLR for severe bronchiectasis, according to the different multidimensional scores. Mean age: 69 (15) years (66.3% of women). The mean NLR was 2.92 (2.03). A higher NLR was associated with more severe bronchiectasis (with an especially significant discriminative power for severe forms) according to the commonly used scores (FACED, E-FACED and BSI), as well as with poorer quality of life (SGRQ), more comorbidities (Charlson index), infection by pathogenic microorganisms, and greater application of treatment. Furthermore, the NLR correlated better with severity scores than other parameters of systemic inflammation. Finally, it was an independent predictor of the incident number and severity of exacerbations. In conclusion, the NLR is an inexpensive and easy-to-measure marker of systemic inflammation for determining severity and predicting exacerbations (especially the most severe) in patients with bronchiectasis. MDPI 2022-09-30 /pmc/articles/PMC9599714/ /pubmed/36291608 http://dx.doi.org/10.3390/biom12101399 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martinez-García, Miguel Ángel Olveira, Casilda Girón, Rosa García-Clemente, Marta Máiz-Carro, Luis Sibila, Oriol Golpe, Rafael Méndez, Raúl Rodríguez Hermosa, Juan Luis Barreiro, Esther Prados, Concepción Rodríguez López, Juan de la Rosa, David Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity |
title | Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity |
title_full | Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity |
title_fullStr | Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity |
title_full_unstemmed | Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity |
title_short | Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity |
title_sort | peripheral neutrophil-to-lymphocyte ratio in bronchiectasis: a marker of disease severity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599714/ https://www.ncbi.nlm.nih.gov/pubmed/36291608 http://dx.doi.org/10.3390/biom12101399 |
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